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Diss Factsheets
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EC number: 607-233-2 | CAS number: 2343-89-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
There are no toxicokinetic studies available for this substance however an assessment of the likely toxicokinetic properties can be made from the available phys-chem and toxicology data.
The substance is a light brown liquid that remains liquid to <20°C. Its measured boiling point is 89.8 ± 1.0 °C (362.9 ± 1.0 K) at 99.4 kPa. The molecular weight is low at 104.08 g/mol. The mean measured Log P (octanol-water) is 0.931 and the mean measured water solubility is 25.9 g/l at 20 degC. Therefore it is moderately soluble in water. The vapour pressure value 7.1 x 103Pa at 25 degC shows that the substance is a moderately volatile at room temperature (akin to ethanol).
Absorption: There are no specific ADME data on the extent to which the substance absorbs across the gut, lungs or skin. The level of absorption will depend upon the solubility in the solvent/vehicle carrying it into the body. It is a low molecular weight chemical and therefore, if solubilised could undergo some absorption across the gut. The two main potential routes of exposure are via ingestion or dermal contact. Severe acute toxicological effects seen in the acute dosing study at 300 mg/kg using oral gavage, suggest that the majority of this dose given orally is likely to have absorbed systemically across the gut. In dosing oral toxicological studies, arachis oil was chosen as the vehicle. Its logPo/w, water solubility and low molecular weight would make for a good expected level of absorption across the gut. There are no specific skin absorption data. Given the low logPo/w, this material is not optimal for skin penetration, but it is of low molecular weight. The acute dermal LD50 is high at >2000 mg/kg, suggesting dermal absorption is low. This compound may also be expected to volatilise from the skin surface. The substance is not irritant/corrosive and therefore no damage to the skin barrier is expected upon contact.
Distribution: There are observations of pale liver and pale kidney, from the acute toxicity study at 300 mg/kg that the substance could have reached these particular organs. The high level of systemic toxicity seen acutely, would also suggest distribution to major organs had occurred. Given the water solubility and low molecular weight it would be expected that this substance would distribute quickly around the body to most if not all organs.
Metabolism: The substance would be expected to hydrolyse via ubiquitous esterase enzymes in the body to methanol and 2-fluoropropenoic acid.
Excretion: There is no evidence to indicate the route of excretion. Any substance that is mainly absorbed across the gut will be excreted predominantly in the urine. These small molecules would be expected to be cleared by the liver and kidney.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.