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EC number: 613-971-6 | CAS number: 66654-01-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 72 h
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study conducted according to guideline method with restriction. Restriction: The stability of the test concentrations was not verified with analytical monitoring.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
- Report date:
- 1994
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 201 (Alga, Growth Inhibition Test)
- Qualifier:
- according to guideline
- Guideline:
- other: DIN 38412/9 (May 1989)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Amides, C8-18 even numbered, N-[3-(dimethylamino)propyl]
- IUPAC Name:
- Amides, C8-18 even numbered, N-[3-(dimethylamino)propyl]
- Reference substance name:
- 930-947-3
- EC Number:
- 930-947-3
- IUPAC Name:
- 930-947-3
- Details on test material:
- - Name of test material (as cited in study report): Tego-Amid D 5040
- Analytical purity: 89,39 %
Constituent 1
Constituent 2
Sampling and analysis
- Analytical monitoring:
- no
Test solutions
- Vehicle:
- no
Test organisms
- Test organisms (species):
- Desmodesmus subspicatus (previous name: Scenedesmus subspicatus)
- Details on test organisms:
- TEST ORGANISM
- Source: Pflanzenphysiologisches Institut Göttingen
- Age of inoculum (at test initiation):
- Method of cultivation: Cultivation in Erlenmeyer flasks (300 ml), filled with culture medium. Constant movement on a mechanical shaker. Illumination with white fluorescent tube (2000 lux).
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 72 h
Test conditions
- Test temperature:
- 23 +- 2 °C
- pH:
- not reported
- Nominal and measured concentrations:
- nominal concentrations: control; 0.025; 0.05; 0.075; 0.1; 0.25; 0.5; 0.75 mg/l
- Details on test conditions:
- TEST SYSTEM
- Initial cells density: 10 000 cells/ ml
- Control end cells density: 271E3 cells/ml
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 3
GROWTH MEDIUM
- Standard medium used: not reported, probably yes
OTHER TEST CONDITIONS
- Adjustment of pH: not reported
- Photoperiod: constant illumination
- Light intensity and quality: 2000 lux with white fluorescent tubes
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
- Determination of cell concentrations: fluorimeter at Ex 485; Em 685 nm in 1 ml cuvettes
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- 0.18 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- biomass
- Duration:
- 72 h
- Dose descriptor:
- EC10
- Effect conc.:
- 0.05 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- biomass
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- 0.36 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Duration:
- 72 h
- Dose descriptor:
- EC10
- Effect conc.:
- 0.1 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Details on results:
- - Exponential growth in the control (for algal test): yes
- Reported statistics and error estimates:
- statistcal method: linear regression
Any other information on results incl. tables
Avarage cell number [x1000/ml]
Concentration |
24 h |
48 h |
96 h |
Control |
21 |
96 |
271 |
0.025 |
23 |
118 |
291 |
0.05 |
31 |
77 |
263 |
0.075 |
21 |
50 |
230 |
0.1 |
13 |
48 |
209 |
0.25 |
16 |
40 |
177 |
0.5 |
13 |
17 |
43 |
0.75 |
11 |
12 |
13 |
Biomass after 72 h:
Concentration |
Biomass integral x 1000 |
% Inhibition |
Control |
5460 |
|
0.025 |
6276 |
- 15 |
0.05 |
5148 |
6 |
0.075 |
3864 |
29 |
0.1 |
3612 |
34 |
0.25 |
2868 |
47 |
0.5 |
636 |
88 |
0.75 |
108 |
98 |
Growth rater after 72 h:
Concentration |
Growth rate |
% Inhibition |
Control |
45,8 |
|
0.025 |
46,8 |
- 2 |
0.05 |
45,4 |
1 |
0.075 |
43,5 |
5 |
0.1 |
42,2 |
8 |
0.25 |
39,9 |
13 |
0.5 |
20,3 |
56 |
0.75 |
3,6 |
92 |
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Static acute toxicity test according to OECD TG 201 with Scenedesmus subspicatus. Test meets validity criteria of the guideline. No analytical monitoring was made. Therefore the test results are based on nominal concentration.
ErC50 (72 h) = 0.36 mg/l
ErC10 (72 h) = 0.1 mg/l
EbC50 (72 h) = 0.18 mg/l
EbC10 (72 h) = 0.05 mg/l - Executive summary:
Static acute toxicity test according to OECD TG 201 with Scenedesmus subspicatus. Test meets validity criteria of the guideline. No analytical monitoring was made. Therefore the test results are based on nominal concentration.
ErC50 (72 h) = 0.36 mg/l
ErC10 (72 h) = 0.1 mg/l
EbC50 (72 h) = 0.18 mg/l
EbC10 (72 h) = 0.05 mg/l
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