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Diss Factsheets
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EC number: 210-890-4 | CAS number: 625-36-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- PNEC aqua (freshwater)
- PNEC value:
- 0.045 mg/L
- Assessment factor:
- 1 000
- Extrapolation method:
- assessment factor
- PNEC freshwater (intermittent releases):
- 0.453 mg/L
Marine water
- Hazard assessment conclusion:
- PNEC aqua (marine water)
- PNEC value:
- 0.005 mg/L
- Assessment factor:
- 10 000
- Extrapolation method:
- assessment factor
STP
- Hazard assessment conclusion:
- PNEC STP
- PNEC value:
- 482 mg/L
- Assessment factor:
- 1
- Extrapolation method:
- assessment factor
Sediment (freshwater)
- Hazard assessment conclusion:
- PNEC sediment (freshwater)
- PNEC value:
- 0.335 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Sediment (marine water)
- Hazard assessment conclusion:
- PNEC sediment (marine water)
- PNEC value:
- 0.034 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for air
Air
- Hazard assessment conclusion:
- no hazard identified
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- PNEC soil
- PNEC value:
- 0.04 mg/kg soil dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- no potential for bioaccumulation
Additional information
Due to the rapid hydrolysis of the parent compound, the PNEC derivation is based on the results for the parent compound, its hydrolysis product 3-chloropropionic acid (107-94-8).
Effect values of the hydrolysis product HCl (7647 -01 -0) were not considered in the ecotoxicological evaluation of the substance since the observed toxicity was not due to intrinsic properties of the molecule, but is due to pH effects.
Conclusion on classification
The parent compound rapidly hydrolyses in contact with water and forms 3-chloropropionic acid (107-94-8) and HCl (CAS 7647 -01 -0).
Data from HCl have not been taken into consideration as observed effects are caused by a pH-shift in the test medium. Data for the parent compound itself are available only for short-term toxicity to fish. Acute toxicitty data for the hydrolysis product chloropropionic acid (107-94-8) are available for two trophic levels: aquatic invertebrates and algae; chronic toxicity data are only available for algae.
Therefore, the conclusion on classification will be based on the information available for 3-chloropropionyl chloride and its hydrolysis product 3-chloropropionic acid.
Official classification regarding environmental hazards:
Aquatic compartment
According to Regulation (EC) No 1272/2008 Annex VI Table 3.1 the substance holds no relevant classification.
According to Regulation (EC) No. 1272/2008 Annex VI Table 3.2 the substance holds no relevant classification.
Self-classification
Aquatic compartment
Following GHS, the substance is not to be classified as acutely or chronically hazardous to the aquatic environment.
Rationale:
The substance is not to be classified as acutely hazardous to the aquatic environment, since the lowest acute effect value is > 1 mg/L.
Chronic data are available for algae; therefore, classification is based on the available chronic and acute toxicity data.
- Chronic toxicity data:
Chronic data are available for algae (Desmodesmus subspicatus, 72-h ErC10 = 10.1 mg/L; ECHA disseminate data, 2015), indicating that the substance does not present a long-term hazard according to the categories outlined in Table 4.1.0(b) (ii) (Commission Regulation (EU) No 286/2011 amending Regulation (EC) No 1272/2008) for rapidly degradable substances. Based on the chronic data for the hydrolysis product methanol, the parent compound is not to be classified as chronically hazardous to the aquatic environment as the lowest chronic effect value is clearly higher than 1 mg/L
- Acute toxicity data:
The lowest effect value (LC/EC50) for acute toxicity to aquatic organisms (fish and aquatic invertebrates) is >10 and ≤. 100 mg/L.
However, the parent compound hydrolyses to form 3-chloropropionic acid. The hydrolysis product is readily biodegradable (Trénel J. and Kühn R., 1982). Log Kow values of the parent compound and its hydrolysis product are <4. Therefore, based on the available data for the hydrolysis product 3-chloropropionic acid and for the parent compound itself, the parent compound is not to be classified as chronically hazardous to the aquatic environment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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