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Diss Factsheets
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EC number: 203-572-1 | CAS number: 108-32-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study is presented in a Japanese journal with english abstract. Handwritten translation included. Journal not identified.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 972
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The LD50 in rats and mice after a single subcutaneous injection of the test substance was determined.
- Limit test:
- no
Test material
- Reference substance name:
- Propylene carbonate
- EC Number:
- 203-572-1
- EC Name:
- Propylene carbonate
- Cas Number:
- 108-32-7
- Molecular formula:
- C4H6O3
- IUPAC Name:
- 4-methyl-1,3-dioxolan-2-one
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): propylene carbonate
- Stability under test conditions: Forms a stable solution in water
- Other: Colorless (transparent)
Test animals
- Species:
- other: Mouse and rat
- Strain:
- other: dd-strain mice and Wistar strain rats
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: Approximately 20 g (mice); 180 g (rats)
- Diet: Properly fed for 7 days. During the experiment, food was provided ad libitum.
- Water: ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 23-27 C
Administration / exposure
- Route of administration:
- subcutaneous
- Vehicle:
- unchanged (no vehicle)
- Details on exposure:
- Animals were given one injection and observed for 72 hours after treatment.
- Doses:
- - Mice: 9.6, 11.6, 13.9, 16.7, or 20.0 mL/kg
- Rats: 6.7, 8.0, 9.6, 11.6, 13.9, 16.7, or 20.0 mL/kg - No. of animals per sex per dose:
- 10 males/dose
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 72 hours
- Necropsy of survivors performed: yes - Statistics:
- LD50 was calculated according to the method of Van der Waerden.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 15.8 mL/kg bw
- 95% CL:
- 14.6 - 17.2
- Remarks on result:
- other: Mice
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 11.1 mL/kg bw
- 95% CL:
- 10.3 - 11.9
- Remarks on result:
- other: Rats
- Mortality:
- Mice: No animals in the 9.6 or 11.6 mL/kg groups died. In the 13.9 mL/kg group, 3 animals died, all at 12 hours. In the 16.7 mL/kg group, 1 animal died at hour 1 and 4 more died at hour 12. In the high dose group (20.0 mL/kg), all animals died, 4 at hour 1 and the remaining 6 animals at hour 12.
Rats: No animals died in the 6.7 and 8.0 ml/kg groups. In the 9.6, 11.6, 13.9, and 16.7 ml/kg groups, 1, 8, 9, and 10 animals, respectively, died at hour 12; no additional deaths occurred. In the high dose group (20.0 mL/kg), 2 animals died at hour 1 and the remaining 8 died at hour 12. - Clinical signs:
- Decreased activity was generally observed
Applicant's summary and conclusion
- Conclusions:
- The male rat subcutaneous LD50 was determined to be 11.1 mL/kg.
The male mouse subcutaneous LD50 was determined to be 15.8 mL/kg.
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