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Diss Factsheets
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EC number: 209-406-4 | CAS number: 577-11-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Solubility in organic solvents / fat solubility
Administrative data
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: EU A.6
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: Slow-stir method as referred in the ECHA document 'Guidance on information requirements and chemical safety assessment, Chapter R.7a: Endpoint specific guidance' (May 2008)
- Principles of method if other than guideline:
- The solubility of Docusate Sodium in n-octanol at 20 °C was investigated in analogy to the slow-stir method
as referred in the ECHA document 'Guidance on information requirements and chemical safety assessment,
Chapter R.7a: Endpoint specific guidance' (May 2008). Basic principles and requirements of the water solubility
method EC A.6 were followed. - GLP compliance:
- no
Test material
- Reference substance name:
- Docusate sodium
- EC Number:
- 209-406-4
- EC Name:
- Docusate sodium
- Cas Number:
- 577-11-7
- Molecular formula:
- C20H38O7S.Na
- IUPAC Name:
- sodium 1,4-bis[(2-ethylhexyl)oxy]-1,4-dioxobutane-2-sulfonate
- Details on test material:
- - Name of test material (as cited in study report): Docusate Sodium / AEROSOL® OT-100% Surfactant
- Substance type: detergent
- Physical state: colourless solid, shape of thin layers wrapped like a bolt
- Analytical purity:>97 %
- Impurities (identity and concentrations):
Water (CAS 7732-18-5), <2 %
2-Ethylhexanol (CAS 104-76-7), <1 %
Bis(2-ethylhexyl)maleate (CAS 142-16-5), <0.5 %
Sodium sulfate (CAS 7757-82-6), <0.5 %
Sodium bisulfite (CAS 7631-90-5), <0.2 %
- Lot/batch No.: SU9091805
Constituent 1
Results and discussion
Solubility in organic solvents / fat solubility
- Medium:
- n-octanol
- Solubility:
- 814 g/L
- Temp.:
- 20 °C
- Test substance stable:
- yes
Any other information on results incl. tables
|
The highest result of the n-octanol solubility differed from the lowest one by less than 15%. Therefore all results were used for further
calculations. The solubility of the test substance in n-octanol at 20 °C was obtained by calculating the mean value of all results. The mean value is 841 g/l.
The most important contribution to the uncertainty of the result comes from the distribution of analytical measurements. The standard deviation of the results was calculated to be 7 g/l, giving an expanded uncertainty of 14 g/l (coverage factor k=2). An additional contribution to the uncertainty of the solubility arises from the fact that the test substance might be contaminated by sulfur containing compounds (see composition chap. 2.4). Unfortunately, there are to many unknown parameters related to this problem in order to discuss the contribution to the uncertainty on a theoretical basis. These parameters are for example the true content of each of these contaminations, the solubility of the contaminations in the presence of the main component, the influence of the
contaminations on the solubility of the main component etc.
Thus the final result for the solubility of Docusate sodium in n-octanol at 20 °C is 841 ± 14 g/l.
Applicant's summary and conclusion
- Conclusions:
- The n-octanol solubility is 814 g/L
- Executive summary:
The n-octanol water solubility of Docusate Sodium at 20 °C was investigated by the slow-stir method as referred in the ECHA document 'Guidance on information requirements and chemical safety assessment, Chapter R.7a: Endpoint specific guidance' (May 2008). Basic principles and requirements of the established method EC A.6 were followed. The concentration in the saturated solution was determined by XRF measurement to be 814 ± 14 g/l..
The results of this study are considered to be acceptable for the risk assessment.
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