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Diss Factsheets
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EC number: 255-255-2 | CAS number: 41198-08-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
- Endpoint:
- basic toxicokinetics
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
Reference
Description of key information
Key value for chemical safety assessment
Additional information
The following summary is taken form the JMPR evaluation of Profenofos conducted in 2007:
[Phenyl-14C]profenofos was rapidly absorbed and eliminated after oral administration to rats. Total radioactivity eliminated via the urine and faeces exceeded 99% of the administered dose for a single dose of 1 or 100 mg/kg bw by gavage and repeated doses of 1 mg/kg bw by gavage. Elimination was rapid, with about of 95% of the total radiolabel being excreted in the urine within the first 24 h in all treated groups. For all doses, less than 4% of the radiolabel was excreted in the faeces. The concentration of radiolabel in tissues and organs reached a maximum after 2 h and remained at similar levels until 8 h after dosing. By 72 h, the tissue concentration of radiolabel was minimal. The absorption, distribution and excretion of 14C-labelled profenofos was not sex- or dose-dependent in the range of 1 to 100 mg/kg bw and was unaffected by pre-treatment with unlabelled profenofos for 14 days. Unchanged profenofos was detected in the faeces, but the amount was very small (approximately 1–2% of the administered dose), and this was probably the proportion of the dose that was not absorbed. Four major metabolites were present in urine and no unchanged profenofos was detected. The major metabolites were the sulfate and glucuronide conjugates of 4-bromo-2-chlorophenol that were formed by hydrolysis of the aryloxy–phosphorus bond followed by conjugation with sulfate or glucuronic acid. The other two metabolites were formed by cleavage of the phosphorus– sulfur bond either by loss of the propyl group or hydrolysis. The 4-bromo-2-chloro-phenol was detected in some urine samples, but probably arose as a result of hydrolysis of the conjugates after excretion.
References:
JMPR (2007). Pesticide residues in food. Joint FAO/WHO meeting on pesticide residues. Report of the Joint Meeting of the FAO Panel of Experts on Pesticide Residues in Food and the Environment and the WHO Core Assessment Group on Pesticide Residues. Geneva, Switzerland, 18 -27 September 2007.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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