Registration Dossier
Registration Dossier
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EC number: 203-294-0 | CAS number: 105-39-5
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
Based on the QSAR estimation using the OECD Toolbox v1.1, the substance is considered to be a skin sensitiser.
Furthermore, as published in an article, the substance monochloro acetic acid ethyl ester (EMCA) was tested in the Guinea Pig Maximization Test (Magnusson and Kligman) to determine its possible sensitizing potential. EMCA showed the capacity to sensitize 5 of 20 guinea pigs. EMCA is concluded to be a sensitizer to humans.
Migrated from Short description of key information:
Weight of evidence: results published in an article with the substance monochloro acetic acid ethyl ester and QSAR estimation using the OECD Toolbox.
Justification for classification or non-classification
Based on the results observed on the publication and the results based on QSAR estimations, the substance ethyl chloroacetate is considered a skin sensitizer. According to the CLP Regulation, the substance is classified as Skin Sensitizer Category 1.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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