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Diss Factsheets
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EC number: 213-063-6 | CAS number: 921-03-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Carcinogenicity
Administrative data
- Endpoint:
- carcinogenicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1989
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: following a guideline with limited documentation, only for skin tumors
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Mouse skin assay with topically administered 50 mg/kg of test material, administered 6 times over 2 weeks (all together 300 mg/kg)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 1,1,3-trichloroacetone
- EC Number:
- 213-063-6
- EC Name:
- 1,1,3-trichloroacetone
- Cas Number:
- 921-03-9
- Molecular formula:
- C3H3Cl3O
- IUPAC Name:
- 1,1,3-trichloropropan-2-one
- Details on test material:
- - Name of test material (as cited in study report): 1,1,3-Trichloroacetone
- Physical state: liquid
- Analytical purity: 95
- Impurities (identity and concentrations): 1,3-Dichloroacetone (1.4%), 1,1,3,3-Tetrachloroacetone
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- Sencar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- Sencar mice from Harlan-SpragueDawley, Indianapolis, IN, USA
Administration / exposure
- Route of administration:
- dermal
- Vehicle:
- ethanol
- Details on exposure:
- 300 mg/kg
- Analytical verification of doses or concentrations:
- not specified
- Details on analytical verification of doses or concentrations:
- not applicable
- Duration of treatment / exposure:
- 6 administrations each 50 mg/kg
- Frequency of treatment:
- 6 times/ 2 weeks
- Post exposure period:
- 24 weeks
Doses / concentrations
- Remarks:
- Doses / Concentrations:
300 mg/kg
Basis:
nominal conc.
- No. of animals per sex per dose:
- 39 animals
- Control animals:
- yes, concurrent vehicle
- Details on study design:
- - Dose selection rationale: toxcicity
- Rationale for animal assignment (if not random): random - Positive control:
- not applicable
Examinations
- Observations and examinations performed and frequency:
- not reported
- Sacrifice and pathology:
- not reported
- Other examinations:
- none reported
- Statistics:
- cumulative tumor count with log rank test
Results and discussion
Results of examinations
- Clinical signs:
- not specified
- Mortality:
- not specified
- Body weight and weight changes:
- not specified
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- not specified
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- not specified
- Behaviour (functional findings):
- not specified
- Organ weight findings including organ / body weight ratios:
- not specified
- Gross pathological findings:
- not specified
- Histopathological findings: non-neoplastic:
- not specified
- Histopathological findings: neoplastic:
- effects observed, treatment-related
- Details on results:
- tumors below control groups
- Relevance of carcinogenic effects / potential:
- Amount of tumors induced is statistically not significant
Applicant's summary and conclusion
- Conclusions:
- 1,1,3-Trichloroacetone showed no statistically relevant induction of tumors under the conditions used.
- Executive summary:
In a mouse skin assay 1,1,3 -trichloroacetone was assessed for its ability to induce skin tumors after repeated application. 39 female Sencar mice were administered with 50 mg/kg test substance in 0.2 ml ethanol for 6 times within two weeks. Control animals received 0.2 ml ethanol per application. Two weeks after the final dose, 1.0µg TPA (12-O-tetradecanoyl-phorbol-13-acetate) in 0.2 ml acetone was applied three times weekly for 20 weeks. After 24 weeks the percentage of animals with tumors was determined in order to classify the carcinogenetic activity of the test substance. 1,1,3-Trichloroacetone showed no statistically relevant induction of tumors in the mouse skin under the conditions used.
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