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EC number: 254-588-0 | CAS number: 39670-09-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study OECD 405. GLP. Meets generally accepted scientific principles, acceptable for assessment.
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 1 998
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 999
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Version / remarks:
- adopted 24 February 1987
- Deviations:
- no
- GLP compliance:
- yes
- Remarks:
- adopted 12th May 1981
Test material
- Reference substance name:
- 2-[2-(2-ethoxyethoxy)ethoxy]ethyl methacrylate
- EC Number:
- 254-588-0
- EC Name:
- 2-[2-(2-ethoxyethoxy)ethoxy]ethyl methacrylate
- Cas Number:
- 39670-09-2
- Molecular formula:
- C12H22O5
- IUPAC Name:
- 2-[2-(2-ethoxyethoxy)ethoxy]ethyl methacrylate
- Reference substance name:
- Ethyltriglycol methacrylate
- IUPAC Name:
- Ethyltriglycol methacrylate
- Details on test material:
- - Name of test material (as cited in study report): Methacrylate d'ethyltriglycol (ETGMA)
- Substance type: organic
- Physical state: liquid
- Supplier: Elf Atochem S.A., 92091 Paris, France
- Storage condition of test material: + 4°C and protected from light
Constituent 1
Constituent 2
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: New Zealand White rabbits, Supplier: Elevage Cunicole du Val de Selle, 80160 Prouzel, France
- Age at study initiation: no data
- Weight at study initiation: 2.9 ±0.05 kg
- Housing: individually in polystyrene cages (35 x 55 x 32 cm or 48.2 x 58 x 36.5 cm)
- Diet: ad libitum during study
- Water: ad libitum during study
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 ±3 °C
- Humidity (%): 50 ±20 %
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): 12 hrs dark / 12 hrs light
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated eye of each treated animal serves as controll
- Amount / concentration applied:
- undiluted
Amount applied: 0.1 ml
The eyes were not rinsed after administration of the test substance. - Duration of treatment / exposure:
- 72 hour(s)
- Observation period (in vivo):
- 21 days after treatment
- Number of animals or in vitro replicates:
- 3
Results and discussion
In vivo
- Irritant / corrosive response data:
- One hour after instillation of the test substance, some moderate conjunctival reactions (chemosis and redness, score of 2) in 2 animals and marked conjuctival reactions (chemosis, score of 4 and redness, score of 3) in one animal were observed. No iridic or corneal damages were noted in the 3 animals. No ocular reactions were noted thereafter (24, 48 and 72 hours after instillation).
Any other information on results incl. tables
MMAS (Modified Maximum Average Score) (0+0+0)/3 = 0
Classification of eye irritation studies according OECD-GHS-criteria
Substance: Ethyltriglycol methacrylate CAS: 39670 -09 -2
Internal No.: LITSU 01-0120
Date/Expert: 06 -02 -2012/RG
Animal No. |
Corneal opacity/Hornhauttrübung[Scores] |
Mean Draize score |
Reversibility [scores] |
Hazard category |
||||
after 24 h |
after 48 h |
after 72 h |
in 7 days |
in 21 days |
||||
1 |
0 |
0 |
0 |
0 |
- |
- |
||
2 |
0 |
0 |
0 |
0 |
- |
- |
||
3 |
0 |
0 |
0 |
0 |
- |
- |
||
none |
||||||||
Animal No. |
Iritis/Regenbogenhautentzündung[Scores] |
Mean Draize score |
Reversibility [scores] |
Hazard category |
||||
after 24 h |
after 48 h |
after 72 h |
in 7 days |
in 21 days |
||||
1 |
0 |
0 |
0 |
0 |
- |
- |
||
2 |
0 |
0 |
0 |
0 |
- |
- |
||
3 |
0 |
0 |
0 |
0 |
- |
- |
||
none |
||||||||
Animal No. |
Conjunctiva redness (erythem) /Bindehautrötung[Scores] |
Mean Draize score |
Reversibility [scores] |
Hazard category |
||||
after 24 h |
after 48 h |
after 72 h |
in 7 days |
in 21 days |
||||
1 |
0 |
0 |
0 |
0 |
- |
- |
||
2 |
0 |
0 |
0 |
0 |
- |
- |
||
3 |
0 |
0 |
0 |
0 |
- |
- |
||
none |
Animal No. |
Conjunctiva chemosis /Bindehautödem[Scores] |
Mean Draize score |
Reversibility [scores] |
Hazard category |
|||
after 24 h |
after 48 h |
after 72 h |
in 7 days |
in 21 days |
|||
1 |
0 |
0 |
0 |
0 |
- |
- |
|
2 |
0 |
0 |
0 |
0 |
- |
- |
|
3 |
0 |
0 |
0 |
0 |
- |
- |
|
none |
Classification: Hazard Category |
none |
Classification Criteria for serious Eye Damage
Category 1
- Irreversible damage to cornea, iris, conjunctiva 21 days after exposure in at least one animal
- Mean Draize score in 2 of 3 animals:
corneal opacity ≥ 3
iritis ≥ 1,5
Category 2
- Reversible adverse effects on cornea, iris, conjunctiva
- Mean Draize score in 2 of 3 animals:
corneal opacity >= 1
iritis >= 1
redness >= 2
chemosis >= 2
Subcategory 2A
- Reversible in 21 days
Subcategory 2B
- Reversible in 7 days
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Classification: not irritating
- Executive summary:
In a primary eye irritation study according to OECD 405 0.1 mL undiluted Ethyltriglycol methacrylate was instilled into the conjunctival sac of the left eye of 3 New Zealand White rabbits, (body weight at study initiation: 2.9 ±0.05 kg) for 72 hours. The animals were observed for 21 days. Irritation was scored according to Draize scoring and evalutated according OECD-GHS criteria.
In this study Ethyltriglycol methacrylat is not irritating to eyes.
OECD GHS Category: none
EU GHS Category: none
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