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EC number: 274-778-7 | CAS number: 70693-62-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to fish
Administrative data
- Endpoint:
- fish early-life stage toxicity
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2007
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
- Report date:
- 2007
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: US EPA 850.1400
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 210 (Fish, Early-Life Stage Toxicity Test)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Pentapotassium bis(peroxymonosulphate) bis(sulphate)
- EC Number:
- 274-778-7
- EC Name:
- Pentapotassium bis(peroxymonosulphate) bis(sulphate)
- Cas Number:
- 70693-62-8
- Molecular formula:
- H3K5O18S4
- IUPAC Name:
- pentapotassium bis((hydroperoxysulfonyl)oxidanide) hydrogen sulfate sulfate
- Test material form:
- solid
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- Stock solutions were sampled on days 0, 7, 14, 21, 28, 35 and 37.
Test solutions
- Vehicle:
- no
- Details on test solutions:
- not indicated
Test organisms
- Test organisms (species):
- Cyprinodon variegatus
- Details on test organisms:
- TEST ORGANISM
- Common name: sheepshead minnow
- Source: in-house cultures
POST-HATCH FEEDING
- Start date: 1 day following start of hatch
- Type/source of feed: Fry were fed live brine shrimp (Artemia) nauplii and rotifers. Later on standard commercial fish food was added to diet.
- Amount given: Quantity was increased as the test progressed to accommodate the growing fish
- Frequency of feeding: Ad libitum, at least three times daily
FURTHER DETAILS
- Post-hatch transfer time: Day 6 post-hatch all live fry were counted and released into their respective replicate growth chamber.
- Feeding of animals during test: Yes, but not 24 hours preceding termination
- Treatment for disease within 2 weeks preceeding test: No
Study design
- Test type:
- flow-through
- Water media type:
- saltwater
- Limit test:
- no
- Total exposure duration:
- 37 d
- Remarks on exposure duration:
- (28 days post-hatch)
- Post exposure observation period:
- not indicated
Test conditions
- Hardness:
- Not reported
- Test temperature:
- 24.9-25.5°C
- pH:
- 7.4 – 8.1
- Dissolved oxygen:
- 5.9 – 7.6 mg/L
- Salinity:
- 20±3‰
- Nominal and measured concentrations:
- Nominal concentrations of test substance: 28.9, 55.6, 111, 222, 444, 889 µg/L KMPS, corresponding to 13, 25, 50, 100, 200, 400 µg/L KHSO5
Measured concentrations of test substance: Only stock solution of 1.540 mg KHSO5/L were analysed.
Concentrations ranged from 92 to 120%, mean 1.620 mg/L (105% of nominal). - Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Type: open
- Size: 10 L
- Aeration: No
- Renewal rate of test solution: 6 volume additions to each test chamber in a 24-h period, or a cycle rate of at least 5 cycles / hour. Diluter stock solutions were prepared at a target nominal concentration of 1.540 mg KHSO5/L at least once every eight days.
- No. of embryos per egg cup: 25
- No. of vessels per concentration (replicates): 4 test chambers, 100 embryos per treatment group
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: commercial sea salt mix and laboratory fresh water consisting of well water that was demineralised by reverse osmosis
- Conductivity: Not reported
- Salinity: 20±3‰
- Culture medium different from test medium: no
OTHER TEST CONDITIONS
- Adjustment of pH: No
- Photoperiod: 16 h photoperiod daily
- Light intensity: Wide spectrum fluorescent bulbs, 423 to 667 lux
EFFECT PARAMETERS MEASURED: Length, blotted wet weight, mortality
RANGE-FINDING STUDY
- Test concentrations: 0.73, 1.44, 2.89, 5.56, 11.1, 22.2 mg KMPS/L
- Results used to determine the conditions for the definitive study: Egg hatchability was 84, 78, 76, 60, 10, 0, 0% in the control 0.73, 1.44, 2.89, 5.56, 11.1 and 22.2 mg KMPS/L, respectively. Fry mortality ranged from 26 in the 0.73 mg KMPS/L treatment to 100% in the 1.44 mg KMPS/L group. Mean blotted wet weight was 0.0048 and 0.0031 g/fish for control replicates and 0.0016 and 0.018 g/fish for 0.73 mg/L replicates. - Reference substance (positive control):
- no
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 37 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 889 µg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- number hatched
- Remarks:
- egg hatchability
- Duration:
- 37 d
- Dose descriptor:
- LOEC
- Effect conc.:
- > 889 µg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- number hatched
- Remarks:
- egg hatchability
- Duration:
- 37 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 444 µg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- larval development
- Remarks:
- fry survival
- Duration:
- 37 d
- Dose descriptor:
- LOEC
- Effect conc.:
- 889 µg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- larval development
- Remarks:
- fry survival
- Duration:
- 37 d
- Dose descriptor:
- other: MATC (maximum acceptable toxicant concentration)
- Effect conc.:
- 628 µg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- larval development
- Remarks:
- fry survival
- Duration:
- 37 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 444 µg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- length
- Duration:
- 37 d
- Dose descriptor:
- LOEC
- Effect conc.:
- > 444 µg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- length
- Key result
- Duration:
- 37 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 222 µg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- weight
- Remarks:
- blotted wet weight
- Key result
- Duration:
- 37 d
- Dose descriptor:
- LOEC
- Effect conc.:
- 444 µg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- weight
- Remarks:
- blotted wet weight
- Duration:
- 37 d
- Dose descriptor:
- other: MATC
- Effect conc.:
- 314 µg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other:
- Remarks:
- blotted wet weight
- Details on results:
- Details are given under "Remarks on results including tables and figures"
- Results with reference substance (positive control):
- Not applicable
- Reported statistics and error estimates:
- SAS software, NOEC fisher´s exact test, ANOVA, one-tailed Dunnett´s test were used.
Any other information on results incl. tables
Hatch of Sheepshead minnow embryo:
Nominal concentration (µg KMPS triple salt/L) | Egg hatchability (%) | Day hatch > 95% | Fry survival (%) |
Control | 89 | 9 | 97 |
28.9 | 89 | 10 | 89 |
55.6 | 91 | 9 | 96 |
111 | 87 | 9 | 94 |
222 | 89 | 8 | 96 |
444 | 85 | 9 | 86 |
889 | 93 | 12 | 2* |
* Statistically significant different (Dunnett´s test, P=0.05) to control
28-day Post-Hatch length and blotted wet weight of Sheepshead minnow
Nominal concentration (µg KMPS triple salt/L) | Mean standard length (mm) (Standard deviation) | Mean blotted wet weight (g) (Standard deviation) |
Control | 16 (1.4) | 0.139 (0.034) |
28.9 | 15 (1.2) | 0.136 (0.031) |
55.6 | 15 (1.4) | 0.128 (0.036) |
111 | 15 (1.5) | 0.133 (0.037) |
222 | 15 (1.2) | 0.123 (0.029) |
444 | 15 (1.1) | 0.107 (0.027)* |
889 | 13 (-) | 0.065 (0.001)* |
* Statistically significant different (Dunnett´s test, P=0.05) to control
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The study and the conclusions which are drawn from it fulfill the quality criteria (validity, reliability, repeatability). The study was conducted according to the US EPA guideline 850.1400 without significant deviations. Due to limited analytical method, only the stock solution was analysed for KHSO5.
The validity criteria were fulfilled as following: Concentration of dissolved oxygen > 60% saturation throughout the test; Difference of water temperature < 1.5% between test chambers or successive days at any time during test; temperature within range for specific test species; Overall survival of fertilized eggs in controls (and solvent controls) greater than or equal with 75%.
The most sensitive parameter was blotted wet weight. The NOEC based on weight was 222 µg/L. - Executive summary:
Materials and methods
The study assessing the potential effects of KMPS triple salt on Sheepshead minnow embryos and fry during an early life-stage exposure was performed according to the US EPA guideline 850.1400.
Results and discussion
Due to the limitations of the analytical method, the monitoring of the test substance concentration was not performed. However, stock solutions were analysed. Results are based on nominal concentrations.
Hatching success in the control was 89% and ranged from 85 to 93% in the test item treatments without significant differences to the control. Post hatch survival of fry in the control was 97% and ranged from 2 to 96% in the treatments, with significant effects in the highest concentration. Blotted wet weight was significantly reduced at 444 and 889 µg/L, while mean length was not significantly different compared to the control.
NOEC = 222 µg KMPS/L blotted wet weight
LOEC = 444 µg KMPS/L blotted wet weight
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