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Diss Factsheets
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EC number: 231-391-8 | CAS number: 7529-22-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
- Endpoint:
- bioaccumulation in aquatic species, other
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Reason / purpose for cross-reference:
- reference to other study
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Rainbow trout and zebra mussel were exposed to a single concentration of NMMO during 3 months. Sampling and analysis of concentrations in whole organisms and tissues was performed at the end of the exposure period.
- GLP compliance:
- no
- Radiolabelling:
- no
- Details on sampling:
- Samples of the animals and tissues (only for fish: liver, kidney, muscle) were taken once, at the end of the 3 month exposure period.
- Vehicle:
- no
- Details on preparation of test solutions, spiked fish food or sediment:
- Stock solutions were newly prepared each third day.
- Test organisms (species):
- other: Oncorhynchus mykiss and Dreissena polymorpha
- Details on test organisms:
- Oncorhynchus mykiss = rainbow trout (fish)
- Age: 1-year-old
- Weight: average 18 g (initially)
- Source: der Fischzucht Achleitner in Mattighofen
- Feeding during the test: daily, with Tagger C19/888
Dreissena polymorpha = zebra mussel (invertebrate)
- Source: Traunsee, sampled from a depth of 2-3 m
- Feeding during the test: daily, with fresh yeast or finely homogenized Tetramin - Route of exposure:
- aqueous
- Test type:
- not specified
- Water / sediment media type:
- natural water: freshwater
- Total exposure / uptake duration:
- 92 d
- Hardness:
- 110 mg CaCO3/L
- Test temperature:
- 12.0°C (October), 10.2°C (November), 7.5°C (December)
- pH:
- 8.2
- Dissolved oxygen:
- high, continuous aeration
- TOC:
- no data
- Salinity:
- not applicable
- Details on test conditions:
- TEST SYSTEM
- Test vessel: 24-L aquaria
- Aeration: continuous
- Continuous flow-through system, peristaltic, 465-572 mL/min for fish, 288-369 mL/min for mussels
- No. of organisms per vessel: for fish: 30 (initially, only 11 were sampled at day 92, not clear how many were used for whole organism / tissue analysis) / for mussels: not reported
- No. of vessels per concentration (replicates): 2
- No. of vessels per control / vehicle control (replicates): 2
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: activated carbon-filtered tap water
- Frequent measurement of test substance concentrations (12x in 3 months) and ammonia concentrations (6-9x in 3 months)
OTHER TEST CONDITIONS
- Photoperiod: 12L:12D - Nominal and measured concentrations:
- Single exposure concentration (nominal): 10 mg/L NMMO
Measured concentration: 7.1-12.0 mg/L - Details on estimation of bioconcentration:
- Concentration in tissue / concentration in water = BCF
- Type:
- BCF
- Value:
- < 10 L/kg
- Basis:
- whole body w.w.
- Calculation basis:
- steady state
- Remarks on result:
- other: for both rainbow trout and zebra mussel
- Remarks:
- Conc.in environment / dose:10 mg/L
- Details on results:
- None of the chromatograms showed the presence of NMMO in whole organisms/tissues. The NMMO concentration is therefore < 100 mg/kg
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The BCF is < 10 L/kg, which confirms that the substance has no specific capacity for bioaccumulation in aquatic organisms.
- Executive summary:
In this study, rainbow trout (Oncorhynchus mykiss, 1-yr-old) and zebra mussel (Dreissena polymorpha) were exposed to 10 mg/L NMMO during 92 days. The exposure concentration was monitored and remained stable. After 3 months, no NMMO could be detected in whole organisms or tissues, implying that the BCF is < 10 L/kg, which confirms that the substance has no specific capacity for bioaccumulation in aquatic organisms. It must be kept in mind that the single exposure concentration of 10 mg/L is rather low compared to concentrations known to cause toxicity (e.g., acute LC50 of 31200 mg/L in rainbow trout).
- Endpoint:
- bioaccumulation in aquatic species: fish
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the substance has a low potential for bioaccumulation based on log Kow <=3
Referenceopen allclose all
Description of key information
According to REACH Annex IX 9.3 column 2, testing of bioaccumulation is not required if there is no indication for bioaccumulation based on other properties of the substance (for instance log Kow <= 3). The potential for bioaccumulation of the substance is solely driven by lipophilicity as the substance is not surface active or ionisable at environmental pH (pH 4 – 9). Thus, this endpoint can be waived on the basis of low octanol-water partition coefficient. The log Kow of NMMO is -1.20. In conclusion, bioaccumulation testing is not required.
Nevertheless, a study was conducted (Lackner, 1991), providing supporting evidence, that NMMO has no bioaccumulating properties (BCF <10 L/kg).
Key value for chemical safety assessment
Additional information
A single study (Lackner, 1991) investigating bioaccumulation of NMMO in fish (rainbow trout, Oncorhynchus mykiss) and zebra mussel (Dreissena polymorpha) indicated that the substance has no potential for bioaccumulation. After 92 days of exposure to a single concentration (10 mg/L) no NMMO could be traced in whole organisms or tissues. The BCF was therefore < 10 L/kg ww. It should be kept in mind that the exposure concentration was quite low compared to concentrations causing toxic effects to aquatic organisms. Nevertheless, the results of this study confirm what was expected based on the low log Kow of the substance.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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