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Diss Factsheets
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EC number: 205-483-3 | CAS number: 141-43-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 966
- Report date:
- 1966
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-aminoethanol
- EC Number:
- 205-483-3
- EC Name:
- 2-aminoethanol
- Cas Number:
- 141-43-5
- Molecular formula:
- C2H7NO
- IUPAC Name:
- 2-aminoethanol
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Duration of treatment / exposure:
- 1, 5, 15 min, 20 hrs
- Observation period:
- 8 days
- Number of animals:
- 2
- Details on study design:
- TEST SITE
- Area of exposure: 2.5 x 2.5 cm
REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes
- Time after start of exposure: 1, 5 and 15 min, respectively
SCORING SYSTEM: The original scoring system was converted into Draize scores
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Remarks:
- 1 min exposure
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1.5
- Max. score:
- 4
- Reversibility:
- fully reversible within: 8 days
- Irritation parameter:
- edema score
- Remarks:
- 1 min exposure
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- erythema score
- Remarks:
- 5 min exposure
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1.5
- Max. score:
- 4
- Reversibility:
- fully reversible within: 8 days
- Irritation parameter:
- edema score
- Remarks:
- 5 min exposure
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.16
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 h
- Irritation parameter:
- erythema score
- Remarks:
- 15 min exposure
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1.83
- Max. score:
- 4
- Reversibility:
- fully reversible within: 8 days
- Irritation parameter:
- edema score
- Remarks:
- 15 min exposure
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.66
- Max. score:
- 4
- Reversibility:
- fully reversible within: 8 days
- Irritation parameter:
- erythema score
- Remarks:
- 20 hr exposure
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- edema score
- Remarks:
- 20 hr exposure
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1.33
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8 days
- Other effects:
- bleedings and necrosis of the skin
Any other information on results incl. tables
Readings |
Animal |
Exposure period: 1 min |
||
Erythema |
Edema |
Additional findings |
||
1 min |
1 |
2 |
0 |
spotted appearance |
2 |
0 |
0 |
|
|
24 h |
1 |
2 |
0 |
spotted appearance |
2 |
1 |
0 |
|
|
48 h |
1 |
2 |
0 |
spotted appearance |
2 |
1 |
0 |
|
|
72 h |
1 |
2 |
0 |
spotted appearance |
2 |
0 |
0 |
|
|
8 d |
1 |
0 |
0 |
slight desquamation |
2 |
0 |
0 |
|
|
Mean 24, 48, 72 h |
1 |
2 |
0 |
|
2 |
0.66 |
0 |
|
|
Mean 24, 48, 72 h |
1-2 |
1.33 |
0 |
|
Readings |
Animal |
Exposure period: 5 min |
||
Erythema |
Edema |
Additional findings |
||
5 min |
1 |
2 |
0 |
pea-sized spotted erythema, bleedings |
2 |
3 |
0 |
bleedings |
|
24 h |
1 |
2 |
0 |
spotted appearance |
2 |
2 |
2 |
grey-brown appearance |
|
48 h |
1 |
2 |
0 |
spotted appearance |
2 |
0 |
0 |
leather-like necrosis |
|
72 h |
1 |
2 |
0 |
spotted appearance |
2 |
0 |
0 |
brown-red leather-like necrosis, partly anaemic |
|
8 d |
1 |
0 |
0 |
pea-sized crusts, desquamation |
2 |
0 |
0 |
brown-red leather-like necrosis, partly anaemic |
|
Mean 24, 48, 72 h |
1 |
2 |
0 |
|
2 |
1 |
0.33 |
|
|
Mean 24, 48, 72 h |
1-2 |
1.5 |
0.16 |
|
Readings |
Animal |
Exposure period: 15 min |
||
Erythema |
Edema |
Additional findings |
||
15 min |
1 |
2 |
0 |
bleedings |
2 |
3 |
0 |
bleedings |
|
24 h |
1 |
2 |
2 |
pea-sized brown erythema |
2 |
2 |
0 |
grey-brown spotted appearance, bleedings |
|
48 h |
1 |
2 |
2 |
pea-sized brown erythema |
2 |
0 |
0 |
leather-like anaemic necrosis exceeding area of exposure |
|
72 h |
1 |
3 |
0 |
pea-sized crusts, spotted appearance |
2 |
0 |
0 |
brown-red leather-like necrosis, partly anaemic |
|
8 d |
1 |
0 |
0 |
pea-sized crusts, desquamation |
2 |
0 |
0 |
brown-red leather-like necrosis, partly anaemic |
|
Mean 24, 48, 72 h |
1 |
2 |
1.33 |
|
2 |
1.66 |
0 |
|
|
Mean 24, 48, 72 h |
1-2 |
1.83 |
0.66 |
|
Readings |
Animal |
Exposure period: 20 hours |
||
Erythema |
Edema |
Additional findings |
||
24 h |
1 |
3 |
2 |
grey-brown, exceeding area of exposure |
2 |
3 |
2 |
grey-brown anaemic necrosis, |
|
48 h |
1 |
3 |
2 |
grey-brown, exceeding area of exposure |
2 |
3 |
0 |
black brown hard necrosis |
|
72 h |
1 |
3 |
2 |
black-brown slideable necrosis |
2 |
3 |
0 |
black brown hard necrosis |
|
8 d |
1 |
3 |
2 |
black-brown slideable necrosis |
2 |
3 |
0 |
black brown hard necrosis |
|
Mean 24, 48, 72 h |
1 |
3 |
2 |
|
2 |
3 |
0.66 |
|
|
Mean 24, 48, 72 h |
1-2 |
3 |
1.33 |
|
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (corrosive) based on GHS criteria
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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