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EC number: 237-066-7 | CAS number: 13598-36-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin irritation/corrosion study in rabbits showed that phosphonic acid (80% aqueous solution) is corrosive to skin
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- January 1977
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP study, and no OECD Guideline followed. Acceptable basic data.
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- other: U.N. Transport Regulations; U.S. Federal Regulations
- Deviations:
- not specified
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Bantin and Kingman Ltd.
- Age at study initiation: no data
- Weight at study initiation: 2-3 kg
- Housing: one animal per cage
- Diet: standard rabbit diet
- Water: ad libitum
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS: no data
IN-LIFE DATES: no data - Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- not specified
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 ml
- Concentration (if solution): 80% - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 3 minutes, 1, 4, 24, and 48 hours
- Number of animals:
- 3 males and 3 females
- Details on study design:
- TEST SITE
- Area of exposure: back
- % coverage: 1 inch square
- Type of wrap if used: the patch was covered with an overlapping patch of impermeable plastic adhesive tape. After the final application, the entire trunk was bound with Sleek occlusive tape.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): gently cleansed with water
- Time after start of exposure: 4 hours
SCORING SYSTEM: FDA scoring system, simlar to Draize scoring system - Irritation parameter:
- edema score
- Basis:
- animal: #1,3 and 5
- Time point:
- 24 h
- Score:
- > 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- not determinable
- Remarks:
- Complete breakdown of skin with bleeding - rabbit sacrificed
- Irritation parameter:
- erythema score
- Basis:
- animal: #1,3 and 5
- Time point:
- 24 h
- Score:
- > 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- not determinable
- Remarks:
- Complete breakdown of skin with bleeding -rabbit sacrificed
- Irritation parameter:
- edema score
- Basis:
- animal: #2,4 and 6
- Time point:
- 24 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- edema score
- Basis:
- animal: #2, 4 and 6
- Time point:
- 24 h
- Score:
- > 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- not determinable
- Remarks:
- Dark red brown area
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- animal: All
- Time point:
- other: 48/72h
- Reversibility:
- not reversible
- Remarks on result:
- not determinable
- Remarks:
- Substance corrosive, all animals were sacrificed
- Irritant / corrosive response data:
- At the 1 h reading visible necrosis of the skin was only evident in 2 of the 6 sites treated with this material. However at the 4 h reading all sites treated with phosphorous acid (80%) showed visible necrosis. Visible necrosis was evident at all treated
sites after contact of more than 3 and up to 60 minutes. It was impossible to calculate the primary irritation scores for the materials since for humane reasons the rabbits were sacrificed before the required 72 h reading could be taken. - Interpretation of results:
- other: Cat.1A Corrosive
- Remarks:
- based on CLP 67/548/EEC and 1272/2008.
- Conclusions:
- Phosporous acid (80%) caused visible necrosis at 2 sites after contact for 3-60 minutes in 2 of the 6 sites. The remaining 4 sites showed necrosis after contact of more than 1 hour and up to 4 hours. Based on these results and according to EU criteria Phosporous acid (80%) was considered to be corrosive and the material needs to be classified as Cat.1A Corrosive according to the classification criteria outlined in 67/548/EEC and 1272/2008.
- Executive summary:
A skin corrosion study was conducted, according to U.N. Transport Regulations and U.S. Federal Regulations on 3 male and 3 female New Zealand White rabbits using the test material Phosporous acid (80%). 0.5 ml of the test material was applied under occlusion to the shaved backs of the 6 rabbits. Patch application was repeated after 3 minutes and 1 hour. The test material was not applied at further treatments after 4 hours. Observations for dermal irritation or defects were made at 3 minutes, and 1, 4, 24, and 48 hours after application of the test material. Phosporous acid (80%) caused visible necrosis at 2 sites after contact for 3-60 minutes in 2 of the 6 sites. The remaining 4 sites showed necrosis after contact of more than 1 hour and up to 4 hours. It was impossible to calculate the primary irritation score, since for humane reasons the rabbits were sacrificed before the required 72 hours reading could be taken. Based on these results and according to EU criteria Phosporous acid (80%) was considered to be corrosive and the material needs to be classified as corrosive according to the classification criteria outlined in 67/548/EEC and 1272/2008.
Reference
Oedema mean score (6 rabbits) |
Erythema/Eschar mean score (6 rabbits) |
|
3 minutes | 0 | 0.25 |
1 hour | 0.83 | 2 rabbits visible necrosis |
4 hours | 2 | all 6 rabbits dark red brown area |
24 hours | 3 rabbits dark red brown, and 3 rabbits complete breakdown of skin with bleeding; 4 rabbits sacrificed | |
48 hours | 2 rabbis left: blackened skin, but minimal breakdown |
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
In a skin irritation study, which was performed in accordance with U.N. Transport Regulations and U.S. Federal Regulations, 3 male and 3 female New Zealand White rabbits were exposed to phosphonic acid (80%). Visible necrosis was observed at 2 sites after contact for 3-60 minutes in 2 of the 6 sites. The remaining 4 sites showed necrosis after contact of more than 1 hour and up to 4 hours. Based on these results and according to EU criteria phosphonic acid (80%) was considered to be corrosive to the skin and the material needs to be classified as a Cat.1B Corrosive to skin and eyes according to the classification criteria outlined in 67/548/EEC and 1272/2008.
As phosphonic acid was considered to be corrosive to the skin, an eye irritation study is waived based on column 2 of REACH Annex VIII.
Justification for selection of skin irritation / corrosion
endpoint:
One study was available which was performed similar to the OECD
Guidelines
Justification for selection of eye irritation endpoint:
Studies on eye irritation were waived because phosphonic acid was
classified corrosive to skin
Effects on skin irritation/corrosion: corrosive
Effects on eye irritation: corrosive
Justification for classification or non-classification
The pH of Phosphonic acid is below 1 in a 1% aqueous solution. (see section 7.5.1: combined 28-day repeated dose toxicity study with the reproduction/developmental toxicity screening test of phosphonic acid (phosphorous acid) in rats by oral gavage).
Based on the available information, phosphonic acid should be classified as corrosive for the skin and eyes Category 1A, in accordance with the criteria outlined in Annex VI of 67/548/EEC and Annex I of 1272/2002/EC.
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