Registration Dossier
Registration Dossier
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EC number: 476-900-6 | CAS number: -
Endpoint summary
Administrative data
Description of key information
The acute oral toxicity of the test substance registered when administered by a single oral gavage to rats was assessed in an OECD 423 “Acute Toxic Class Method” study.
The acute dermal toxicity of the test substance registered when administered by a single dermal application to rats was assessed in an OECD 402 study.
No study on acute inhalation was performed with the substance registered.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
The acute oral toxicity of the registered
substance when administered by a single oral gavage to rats was assessed in an OECD 423 “ Acute Toxic Class Method” study. The test substance registered was applied once by oral gavage at a dosage of 2000 mg/kg bw to two groups of three female rats each followed by a 14 day observation period. All animals survived until the end of the study. No clinical signs were observed. Bodyweights of the animals were within the commonly recorded range for this strain. The LD50 oral, rat (female) was greater than 2000 mg/kg bw.
The acute dermal toxicity of the test substance registered when administered by a single dermal application to rats was assessed in an OECD 402 study. Five male and five female rats were treated with the test substance registered at a single dermal dose of 2000 mg/kg bw. Application period was 24 hours followed by a 14 day observation period. No death occurred during the study. No clinical signs were observed. Bodyweights of the animals were within the commonly recorded range for this strain. No macroscopic findings were recorded. The LD50 dermal, rat was greater than 2000 mg/kg.
The test material is non- volatile and produced and handled in industry exclusively in aqueous solutions. There are no spraying operations. Thus, neither exposure via inhalation nor risks are expected via the inhalation route. No Test on acute inhalation toxicity was performed.
Justification for classification or non-classification
No mortality was observed in any of the studies after application of the maximum recommended doses (limit tests). Therefore, the material was not classified.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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