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EC number: 204-857-3 | CAS number: 127-68-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- Data is from BASF
- Qualifier:
- according to guideline
- Guideline:
- other: Refer below
- Principles of method if other than guideline:
- Aim of this study was to determine the effect of test chemical on the growth of fish.
- GLP compliance:
- no
- Analytical monitoring:
- no
- Vehicle:
- not specified
- Test organisms (species):
- Leuciscus idus
- Details on test organisms:
- TEST ORGANISM
- Common name: Golden orfe
- Source: Fa. P. Eggers, Hohenweststedt, bei Neumünster, FRG
- Length at study initiation: 4.4 cm
- Weight at study initiation: 0.96 g
- Corpulence factor of the batch: 1.13
ACCLIMATION
- Acclimation period: 3 days
- Type and amount of food: Holstenstolz, Alleinfutter für Forellen; Typ 34; purchased from Wilhelm Stroeh Jun. KG, FRG
- Feeding frequency: Ad libitum - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Hardness:
- 2.6 mmol/L
5.2 mval/L - Test temperature:
- 20 ± 1°C
- pH:
- 7.7 - 7.9
- Dissolved oxygen:
- 8.3 - 8.9 mg/L
- Nominal and measured concentrations:
- Nominal concentrations: Control and 500 mg/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel: 10 L glass aquaria (30 x 22 x 24 cm)
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 1
- Aeration: Continuous with oil-free air
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: According to guideline
- Alkalinity: 0.8 mmol/L
- Intervals of water quality measurement: Daily
EFFECT PARAMETERS MEASURED: Mortality, symptoms - Reference substance (positive control):
- yes
- Remarks:
- (Chloroacetamide)
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC0
- Effect conc.:
- 500 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 500 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- - Behavioural abnormalities: None
- Mortality of control: None - Validity criteria fulfilled:
- not specified
- Conclusions:
- The lethal concentration (LC50) value of test chemical in fish (Leuciscus idus) in a 96 hr study on mortality effect was determine to be > 500 mg/L.Thus,considering the CLP Criteria for aquatic classification of the substance, it is concluded that the test chemical does not exhibit short term toxicity to fish (Leuciscus idus) within the dose levels mentioned in the study.
- Executive summary:
Aim of this study was to determine the effect of test chemical on the growth of fish.The lethal concentration (LC50) value of test chemical in fish (Leuciscus idus) in a 96 hr study on mortality effect was determine to be > 500 mg/L.Thus,considering the CLP Criteria for aquatic classification of the substance, it is concluded that the test chemical does not exhibit short term toxicity to fish (Leuciscus idus) within the dose levels mentioned in the study.
Reference
Description of key information
Aim of this study was to determine the effect of test chemical on the growth of fish.The lethal concentration (LC50) value of test chemical in fish (Leuciscus idus) in a 96 hr study on mortality effect was determine to be > 500 mg/L.Thus,considering the CLP Criteria for aquatic classification of the substance, it is concluded that the test chemical does not exhibit short term toxicity to fish (Leuciscus idus) within the dose levels mentioned in the study.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 500 mg/L
Additional information
Based on the various experimental data for the test chemical study have been reviewed to determine the toxic nature of test chemical on the growth of fish. The studies are as mentioned below:
Aim of this study was to determine the effect of test chemical on the growth of fish.The lethal concentration (LC50) value of test chemical in fish (Leuciscus idus) in a 96 hr study on mortality effect was determine to be > 500 mg/L.Thus,considering the CLP Criteria for aquatic classification of the substance, it is concluded that the test chemical does not exhibit short term toxicity to fish (Leuciscus idus) within the dose levels mentioned in the study.
First experimental study was supported by the second supporting study from peer reviewed journal The lethal concentration (LC50) value of test chemical in fish (Leuciscus idus, Brachydanio rerio, Salmo gaidneri, Pimephales promelas, Lepomis macrochirus, Poecilia reticulata) in a 24-96 hr study on mortality effect was determine to be >500 - 1350 mg/L. Thus, considering the CLP Criteria for aquatic classification of the substance, it is concluded that the test chemical does not exhibit short term toxicity to fish (Leuciscus idus, Brachydanio rerio, Salmo gaidneri, Pimephales promelas, Lepomis macrochirus, Poecilia reticulata). Thus based on the LC50 chemical was consider as nontoxic and not classified as per the CLP classification criteria.
Similarly in the third supporting study from journal short term toxicity of test chemical was studied on the growth of Lepomis macrochirus under the static system. The lethal concentration (LC50) value of test chemical in fish (Lepomis macrochirus) in a 24 hr study on mortality effect was determine to be < 1350 mg/L. Thus, considering the CLP Criteria for aquatic classification of the substance, it is concluded that the test chemical does not exhibit short term toxicity to fish (Lepomis macrochirus).
The fourth study from other database were used for the test chemical which supports the nontoxic nature of chemical. Short term study was carried out on the growth of fish. The lethal concentration (LC50) value of test chemical in fish (Alburnus alburnus) in a 96 hr study on mortality effect was determine to be 5500 mg/L. Thus, considering the CLP Criteria for aquatic classification of the substance , it is concluded that test chemical does not exhibit short term toxicity to fish (Alburnus alburnus).
Based on the experimental studies from various sources, it was concluded that the test chemical is nontoxic and not classified as per the CLP classification criteria.
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