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Reaction mass of pentasodium 2-{[4-chloro-6-(ethyl{3-[(2-sulfonatoethyl)sulfonyl]phenyl}amino)-1,3,5-triazin-2-yl]amino}-5-hydroxy-6-({2-sulfonato-4-[(4-sulfonatophenyl)diazenyl]phenyl}diazenyl)naphthalene-1,7-disulfonate and tetrasodium 2-[(4-chloro-6-{ethyl[3-(vinylsulfonyl)phenyl]amino}-1,3,5-triazin-2-yl)amino]-5-hydroxy-6-({2-sulfonato-4-[(4-sulfonatophenyl)diazenyl]phenyl}diazenyl)naphthalene-1,7-disulfonate
EC number: 459-580-2 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 22 February 2006 to 10 July 2006
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- Identity: FAT 40824/A
Batch: Red ROE 805 BOP 04/05
Appearance: dark red powder
Purity: Organic part (Na-salt): approx. 82 %; Main component 1 : approx. 36.2 %; Main component 2: approx. 27.5 %; Oligomers: 10%
Expiration date: 01 October 2010
Storage: At room temperature at about 20°C in a desiccator (hygroscopic) - Radiolabelling:
- not specified
- Analytical monitoring:
- yes
- Details on sampling:
- Before and after incubation, 50 µl aliquots of the test solutions at each pH value were analysed without dilution by measuring the UV signal of FAT 40824/A after HPLC separation of the injected sample solution.
- Buffers:
- Buffer pH 4, Biphthalate
Buffer pH 7, Phosphate
Buffer pH 9, Borate - Details on test conditions:
- All glassware, which must be inert in the pH range applied, was rinsed with sterile buffer. The hydrolysis was carried out in flasks, which were stoppered or sealed with an inert material (glass).
- Duration:
- 120 h
- pH:
- 4
- Temp.:
- 50 °C
- Duration:
- 92.8 h
- pH:
- 7
- Temp.:
- 30 °C
- Duration:
- 23.3 h
- pH:
- 7
- Temp.:
- 40 °C
- Duration:
- 7 h
- pH:
- 7
- Temp.:
- 50 °C
- Duration:
- 159.3 h
- pH:
- 9
- Temp.:
- 50 °C
- Duration:
- 66.67 h
- pH:
- 9
- Temp.:
- 60 °C
- Duration:
- 8.8 h
- pH:
- 9
- Temp.:
- 80 °C
- Number of replicates:
- Two aliquots of this test solution of approximately 50 ml each were transferred into 50 ml Erlenmeyer flasks in order to perform a duplicate test.
- Positive controls:
- no
- Negative controls:
- no
- Statistical methods:
- The logarithms of the concentrations were plotted against time (log10 (ct)). If the plot was a straight line, the rate constant and the halflive
time was then calculated using the slope. Otherwise, the rate constant could be estimated by the use of the Arrhenius relationship. - Preliminary study:
- Due to the instability of the test item found in the preliminary test at 50.0 °C, further hydrolysis tests were performed at 50 °C, 40 °C and 30 °C in the buffered test solution at pH 7.0 and at 50 °C, 60 °C and 80 °C in the buffered test solution at pH 9.0.
At pH 4.0 the test item was found to be stable at 50 °C. Therefore, no further testing was performed at this pH-value. - Transformation products:
- not specified
- pH:
- 7
- Temp.:
- 25 °C
- Hydrolysis rate constant:
- 0 s-1
- DT50:
- 90 h
- Type:
- (pseudo-)first order (= half-life)
- pH:
- 7
- Temp.:
- 30 °C
- Hydrolysis rate constant:
- 0 s-1
- DT50:
- 44 h
- Type:
- (pseudo-)first order (= half-life)
- pH:
- 7
- Temp.:
- 40 °C
- Hydrolysis rate constant:
- 0 s-1
- DT50:
- 15 h
- Type:
- (pseudo-)first order (= half-life)
- pH:
- 7
- Temp.:
- 50 °C
- Hydrolysis rate constant:
- 0 s-1
- DT50:
- 4 h
- Type:
- (pseudo-)first order (= half-life)
- pH:
- 9
- Temp.:
- 25 °C
- Hydrolysis rate constant:
- 0 s-1
- DT50:
- 2 530 h
- Type:
- second order
- pH:
- 9
- Temp.:
- 50 °C
- Hydrolysis rate constant:
- 0 s-1
- DT50:
- 98 h
- Type:
- second order
- pH:
- 9
- Temp.:
- 60 °C
- Hydrolysis rate constant:
- 0 s-1
- DT50:
- 31 h
- Type:
- second order
- pH:
- 9
- Temp.:
- 80 °C
- Hydrolysis rate constant:
- 0 s-1
- DT50:
- 4 h
- Type:
- second order
- Validity criteria fulfilled:
- yes
- Conclusions:
- FAT 40824/A is stable at pH 4.0. Its half-life is longer than one year at 25 °C.
The first peak of FAT 40824/A at pH 7.0 has a half-life of 90 hours (4 days) at 25 °C.
The second peak of FAT 40824/A at pH 9.0 has a half-life of 2530 hours (105 days) at 25 °C. - Executive summary:
In a GLP compliant study, the hydrolysis behaviour of FAT 40824/A in aqueous buffered solutions adjusted to pH 4.0, pH 7.0 and pH 9.0. is determined according to OECD Guideline for Testing of Chemicals No. 111, adopted May 12, 1981 and EEC Directive 92/69, Section C.7, L383 A, December 1992.
FAT 40824/A was found to be stable at pH 4.0 at 50°C. Therefore, no further testing was performed at this pH-value. At pH 7.0 and pH 9.0 a specific degradation behaviour was observed. The test item consists of two main components.
At pH 7.0, the first test item peak (retention time at about 17 minutes) decreases and the second test item peak (retention time at about 19 minutes) was stable. The first test item peak was not stable at pH 7.0, further testing was performed at lower temperatures in order to calculate the rate constant (K25) and the half-life of the hydrolysis at pH 7.0 and 25°C.
At pH 9.0 the first peak test item peak increased and the second decreased simultaneously. As FAT 40824/A at pH 9.0 was not stable, further testing was performed at elevated temperatures and observing the second peak in order to calculate the rate constant (k25) and the half-life of the hydrolysis at pH 9.0 and 25°C.
The first peak of FAT 40824/A at pH 7.0 has a half-life of 90 hours (4 days) at 25 °C. The second peak of FAT 40824/A at pH 9.0 has a half-life of 2530 hours (105 days) at 25 °C.
Reference
The results are summarised below (the values typed in italics were calculated using the Arrhenius equation):
pH |
Temperature [°C] |
Reaction rate Constant k [1/hours] |
Reaction rate Constant k [1/s] |
Half-life time t1/2 [hours] |
7.0 |
25 |
7.70x 10-3 |
2.14 x 10-6 |
90 |
50 |
1.73 x10-1* |
4.82 x10-5 |
4 |
|
40 |
4.50x10-2* |
1.25 x10-5 |
15 |
|
30 |
1.57x10-2* |
4.35 X10-6 |
44 |
|
9.0 |
25 |
2.74 x10-4 |
7.61 x 10-8 |
2530 |
50 |
7.08x10-3* |
1.97 x10-5 |
98 |
|
60 |
2.22x10-2* |
6.17 x10-5 |
31 |
|
80 |
1.89x10-1* |
5.25 x10-5 |
4 |
* The tabulated value is the mean of two samples.
FAT 40824/A is stable at pH 4.0. Its half-life is longer than one year at 25°C.
The first peak of FAT 40824/A at pH 7.0 has a half-life of 90 hours (4 days) at 25°C.
The second peak of FAT 40824/A at pH 9.0 has a half-life of 2530 hours (105 days) at 25°C.
Description of key information
The half-life for hydrolysis have been determined at 25 °C as follows:
> 1 year at pH 4.0
90 hours (4days) at pH 7.0
2530 hours (105 days) at pH 9.0
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 90 h
- at the temperature of:
- 25 °C
Additional information
The hydrolysis behaviour of FAT 40824/A in aqueous buffered solutions adjusted to pH 4.0, pH 7.0 and pH 9.0. is determined according to OECD Guideline for Testing of Chemicals No. 111, adopted May 12, 1981 and EEC Directive 92/69, Section C.7, L383 A, December 1992.
The results show that FAT 40824/A is stable at pH 4.0. Its half-life is longer than one year at 25 °C. The first peak of FAT 40824/A at pH 7.0 has a half-life of 90 hours (4 days) at 25 °C. The second peak of FAT 40824/A at pH 9.0 has a half-life of 2530 hours (105 days) at 25 °C.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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