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EC number: 200-662-2 | CAS number: 67-64-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study meets generally accepted scientific principles, minor restriction: only data for female rats; sufficient documentation of test conditions, less detailed documentation of test results; publication acceptable as a key study for acute toxicity
Data source
Reference
- Reference Type:
- publication
- Title:
- Acetone potentiation of acute acetonitrile toxicity
- Author:
- Freeman JJ, Hayes EP
- Year:
- 1 985
- Bibliographic source:
- J Toxicol Environ Health 15: 609-621
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Undiluted acetone applied to female rats by gavage, dose range 5370 - 6980 mg/kg bw, post-observation 14 days for mortality, clinical signs, body weights, necropsy performed
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- Acetone
- EC Number:
- 200-662-2
- EC Name:
- Acetone
- Cas Number:
- 67-64-1
- Molecular formula:
- C3H6O
- IUPAC Name:
- propan-2-one
- Details on test material:
- - Purity: at least 99%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Breeding Laboratories, Wilmington, Mass., USA
- Age at study initiation: not specified
- Weight at study initiation: 174-260 g
- Fasting period before study: overnight fast
- Housing: single
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: at least 7 d
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 5370 to 6980 mg/kg
- No. of animals per sex per dose:
- 5
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: signs of toxicity observed frequently on day of dosing, daily thereafter for 14 days; body weights prior to dosing, at 24, 48, 72 hrs and 7 and 14 days after dosing
- Necropsy performed on rats dying and on survivors: yes
- Other examinations performed: clinical signs, body weight, necropsy (not further specified) - Statistics:
- LGD50 values according to method of Litchfield and Wilcoxon (1948)
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 5 800 mg/kg bw
- Mortality:
- death within 48 to 72 hrs
- Clinical signs:
- other: initial signs: decreased activity and ataxia appeared within 3 hrs; animals appeared recovered after 24 hrs at 32-36 hrs: severe toxicity including tremors, tonus, convulsions signs preceeding death: were a state of prostration, usually without convulsion
- Gross pathology:
- no remarkable differences between dosage groups (no further details)
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Acetone was practically nontoxic based on an oral LD50 value of 5800 mg/kg bw in female rats.
- Executive summary:
Female Sprague-Dawley rats (N=5/group) were orally exposed to doses of 5370 to 6980 mg/kg for determination of LD50. Acetone was practically nontoxic based on an oral LD50 value of 5800 mg/kg bw in rats. Initial signs of intoxication, such as decreased activity and ataxia, appeared within 3 hrs of dosing. Rats appeared to be recovered after 24 hrs. At 32 to 36 hrs severe toxicity was indicated by tremors, tonus, and convulsions, and gradually progressed to death within 48 to 72 hrs. Clinical signs preceeding death were a state of prostration, usually without convulsions. Loss of weight up to 15% occured until 48 hrs after dosing, but started to be reversible at 72 hrs.
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