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EC number: 215-202-6 | CAS number: 1313-13-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Method appears to have been conducted to good scientific standards, although not to GLP. However, in one part of the report it states oral dosing is via stomach intubation, but then the rest of the report appears to indicate ad libitum. It is difficult to know how an insoluble MnO2 would have been administered this way, so this lack of clarity makes it difficult to assign the results as reliable.
Data source
Reference
- Reference Type:
- publication
- Title:
- Studies on the evaluation of the toxicity of various salts of lead, manganese, platinum and palladium
- Author:
- Holbrook DJ, Washington ME, Leake HB and Brubaker PE
- Year:
- 1 975
- Bibliographic source:
- Environmental Health Perspectives, 10:95-101
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Rats were exposed to MnO2 via drinking water for an unspecified period of time. Bodyweights and food/water consumption were measured at 7 day intervals (results not reported).
- GLP compliance:
- no
Test material
- Reference substance name:
- Manganese dioxide
- EC Number:
- 215-202-6
- EC Name:
- Manganese dioxide
- Cas Number:
- 1313-13-9
- Molecular formula:
- MnO2
- IUPAC Name:
- dioxomanganese
- Details on test material:
- - Name of test material (as cited in study report): MnO2
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- 4 rats per cage, food (Purina Laboratory Chow; 56 ± 5 mg Mn/kg feed) and water available ad libitum.
Administration / exposure
- Route of administration:
- oral: drinking water
- Vehicle:
- water
- Doses:
- No data
- No. of animals per sex per dose:
- No data
- Control animals:
- yes
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 3 480 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Conclusions:
- The result of this study indicating an LD50 >> 3480 mg/kg for MnO2 conflicts directly with the current classification of MnO2 which indicates acutely harmful by the oral route. Given the insoluble nature of MnO2 and low bioavailability due to this, it is easier to believe that MnO2 should not be classified as acutely harmful by the oral route and there is no published data which supports this classification. Although assignment of a reliability of 1 or 2 is not possible for this study, the conclusion from this study, that MnO2 is not acutely harmful by the oral route, is very believable.
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