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EC number: 231-195-2 | CAS number: 7446-09-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Entry adopted from the OECD SIAR on sulfur dioxide without modification.Information from subacute inhalation study, study well documented, meets generally accepted scientific principles, no further details reported on type of irritative changes; study acceptable for assessment.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- Effects of exhaust pollutant sulfur dioxide on lipid metabolism on guinea pig organs.
- Author:
- Haider, S.S.
- Year:
- 1 985
- Bibliographic source:
- Indust. Health 23: 81-87
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Study only reports on isolated mechanistic investigations.
- GLP compliance:
- no
Test material
- Reference substance name:
- Sulphur dioxide
- EC Number:
- 231-195-2
- EC Name:
- Sulphur dioxide
- Cas Number:
- 7446-09-5
- Molecular formula:
- SO2
- IUPAC Name:
- Sulphur dioxide generated from sulphur by combustion
- Details on test material:
- - Name of test material (as cited in study report): sulfur dioxide
No further details are given.
Constituent 1
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 250-500 g
- Diet: a pellet diet (Hindustan Lever Ltd., India)
- Water: ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 29-31°C
- Humidity (%): 60%
- Photoperiod: 12 hours dark/light cycle
No further details are given.
Test system
- Type of coverage:
- open
- Preparation of test site:
- not specified
- Vehicle:
- other: air
- Controls:
- yes
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): Test concentration: 10 ppm
- Concentration (if solution):
VEHICLE
- Amount(s) applied (volume or weight with unit):
- Concentration (if solution):
- Lot/batch no. (if required):
- Purity: - Duration of treatment / exposure:
- Exposure time: 30 days, 7 d/w, 1 h/d
- Observation period:
- no data
- Number of animals:
- 24 male guinea pigs: 12 adults and 12 controls
- Details on study design:
- Control animals were kept under normal environmental conditions in the exposure chamber, whereas experimental animals were exposed to the contaminated atmosphere of SO2 (10 ppm) in the exposure chamber. Animals were exposed in a specifically designed exposure chamber for testing atmospheric pollutants by inhalation. The contaminated atmosphere of SO2 in the chamber was obtained by mixing continuously ambient air at the rate of 917 l/min and SO2 9.4 ml/min at a constant rate.
The guinea pigs were killed by decapitation and organs were immediately removed for analysis.
Results and discussion
In vivo
Results
- Irritation parameter:
- other: observations from a 30-day repeated dose toxicity study
- Remarks on result:
- other: Signs of skin irritation are induced by daily 1-hour whole-body exposure of guinea pigs in inhalation chambers to exposure atmospheres containing 10 ppm sulfur dioxide in air.
- Irritant / corrosive response data:
- Nasopharyngitis, preening, increased immobility, skin and eye irritation were the symptoms observed following SO2 toxicosis.
Any other information on results incl. tables
Signs of skin irritation are induced by daily 1-hour whole-body exposure of guinea pigs in inhalation chambers to exposure atmospheres containing 10 ppm sulfur dioxide in air.
Applicant's summary and conclusion
- Conclusions:
- Signs of skin irritation are induced by daily 1-hour whole-body exposure of guinea pigs in inhalation chambers to exposure atmospheres containing 10 ppm sulfur dioxide in air.
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