Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-974-4 | CAS number: 101-77-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Sediment toxicity
Administrative data
Link to relevant study record(s)
- Endpoint:
- sediment toxicity: long-term
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Based on a method described by Phipps GL; Ankley GT; Benoit DA; Mattson VR. 'Use of the aquatic oligochaete Lumbriculus variegatus for assessing the toxicity and bioaccumulation of sediment-associated contaminants'. Environ.Toxicol.Chem., Vol.12, 1993, 269-79 and aspects of OECD draft guideline no. 218 (2001)
- GLP compliance:
- yes (incl. QA statement)
- Details on sediment and application:
- A suspension of sphagnum peat and finely leaves of stinging nettle (Urtica sp) was prepared in reconstituted water. This suspension was used to prepare the artificial sediment which consisted of sand: clay: peat [75:20:5 by dry weight]. The reconstituted water was a solution of recommended quantities of specified inorganic salts in deionised water and was prepared according to OECD Guidleine 203 (1992)
- Test organisms (species):
- Lumbriculus variegatus
- Study type:
- laboratory study
- Test type:
- static
- Water media type:
- freshwater
- Type of sediment:
- artificial sediment
- Duration:
- 28 d
- Exposure phase:
- total exposure duration
- Hardness:
- Measured at the beginning and end of the 28 d exposure period.
- Test temperature:
- 19.5°C (mean value from 36 measurements)
19.1°C - 19.7°C - pH:
- Measured at the beginning and end of the 28 d exposure period.
- Dissolved oxygen:
- Measured every few days of the 28 d exposure period.
- Nominal and measured concentrations:
- Loadings of 3.75, 7.5, 15, 30 and 60 mg MDA.kg-1 sediment (dry weight).
- Duration:
- 28 d
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 60 mg/kg sediment dw
- Basis for effect:
- mortality
- Duration:
- 28 d
- Dose descriptor:
- NOEC
- Effect conc.:
- < 3.75 mg/kg sediment dw
- Basis for effect:
- other: biomass, dry weight
- Duration:
- 28 d
- Dose descriptor:
- EC50
- Effect conc.:
- 42.6 mg/kg sediment dw
- Basis for effect:
- other: biomass, dry weight
- Remarks on result:
- other: calculated
- Duration:
- 28 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 3.75 mg/kg sediment dw
- Basis for effect:
- reproduction
- Duration:
- 28 d
- Dose descriptor:
- EC50
- Effect conc.:
- 14.1 mg/kg sediment dw
- Basis for effect:
- reproduction
- Remarks on result:
- other: calculated
- Duration:
- 28 d
- Dose descriptor:
- LOEC
- Effect conc.:
- 3.75 mg/kg sediment dw
- Basis for effect:
- other: biomass, dry weight
- Details on results:
- Analysis for MDA was not carried out as in the first study with Lumbriculus variegatus (Egeler & Ginzburg 2001) it had been clearly demonstrated that MDA was strongly adsorbed/bound to the sediment.
Reference
Description of key information
Three key studies with different species are available. To assume a worst-case scenario the most sensitive value 3.75 mg/kg dw (Egeler, 2002) achieved with Lumbriculus variegatus was used for PNEC derivation.
Key value for chemical safety assessment
- EC50 or LC50 for freshwater sediment:
- 14.1 mg/kg sediment dw
- EC10, LC10 or NOEC for freshwater sediment:
- 3.75 mg/kg sediment dw
Additional information
Experimental non-guideline studies on three different species representing different feeding and living types associated with sediment are available. The studies were conducted according to GLP regulations and generally accepted scientific principles. All studies are deemed to be long-term and NOEC values ranging from 3.75 to 500 mg MDA/kg sediment (dry weight) were obtained (Egeler, 2002; Egeler & Gilberg, 2005a,b). To assume a worst-case scenario the most sensitive value 3.75 mg/kg dw based on reproduction (Egeler, 2002) achieved with Lumbriculus variegatus was used for PNEC derivation.
Two other non-guideline, GLP study with Lumbriculus variegatus obtained a NOEC of 50.3 mg/l based on survival, reproduction, and biomass after 28 d of exposure to the test item (ECT, 2000) and 25.2 mg/kg dw based on reproduction (Egeler & Ginzburg, 2001). These studies revealed less sensitive values and were therefore used only as additional information and not for PNEC derivation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.