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Diss Factsheets
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EC number: 203-492-7 | CAS number: 107-46-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
There are no reliable data for short-term toxicity to aquatic invertebrates. However, the requirement to test is waived in accordance with Column 2 specific rules for adaptation from Column 1 of REACH Annex VII.
Key value for chemical safety assessment
Additional information
A water-accommodated fraction of the test substance prepared at a loading rate of 1000 mg/L was not toxic to mobility of Daphnia magna over 48 hours when tested at a concentration of 9 parts water-accommodated fraction in 10 parts total volume of test medium. The test medium contained approximately 11 mg/L of silicon. The results indicate that the substance is unlikely to be toxic at its solubility limit of approximately 0.9 mg/L. However this result is disregarded because the concentrations tested are well above the solubility limit of the test substance. The results of two other tests, for which there was insufficient information to assess reliability, also indicated that effects were only observed at nominal loadings that significantly exceeded the solubility of the substance. Using a reliable, validated QSAR method, a worst case EC50 of 0.2 mg/l is estimated; however for substances with a log Kow greater than 5.0, the validation process has indicated that the EC50 would not be reached at the limit of solubility. The log Kow of HMDS (5.06) places this substance on the threshold for quantitative or qualitative application of the ECOSAR predictive method, but it is notable that the qualitative conclusion (EC50 > limit of solubility) appears to be in keeping with the indicative evidence from the available low-reliability experimental studies.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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