Registration Dossier
Registration Dossier
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EC number: 914-129-3 | CAS number: 12336-95-7
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
Data source
Materials and methods
Test material
- Reference substance name:
- Chromium hydroxide sulphate
- EC Number:
- 235-595-8
- EC Name:
- Chromium hydroxide sulphate
- Cas Number:
- 12336-95-7
- Molecular formula:
- CrHO5S
- IUPAC Name:
- chromium hydroxide sulphate
Constituent 1
Results and discussion
Percutaneous absorption
- Remarks on result:
- other:
Applicant's summary and conclusion
- Executive summary:
A number of toxicokinetics studies are available showing that dermal absorption of chromium (III) is very poor. The FIOH document (2006) discusses several dermal absorption studies of chromium (III) compounds and concludes that the low skin permeability of chromium (III) compounds is due to skin barrier rejection of the positive chromium ions. A review by the UK Health and Safety Executive (1989) found that approximately 2% of administered chromium (III), administered in the form of highly water-soluble chromium chloride, was dermally absorbed by guinea pigs after 5 hours. No further testing is therefore required; the HSE has estimated dermal exposure for an exposure duration appropriate to occupational and consumer exposure.
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