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EC number: 200-871-9 | CAS number: 75-45-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- short-term repeated dose toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only short abstract available
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- not reported
- GLP compliance:
- yes
- Limit test:
- yes
Test material
- Reference substance name:
- Chlorodifluoromethane
- EC Number:
- 200-871-9
- EC Name:
- Chlorodifluoromethane
- Cas Number:
- 75-45-6
- Molecular formula:
- CHClF2
- IUPAC Name:
- chlorodifluoromethane
- Details on test material:
- not available
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- Swiss
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Alderly Park Swiss Mice
Administration / exposure
- Route of administration:
- inhalation: gas
- Type of inhalation exposure:
- not specified
- Vehicle:
- air
- Remarks on MMAD:
- MMAD / GSD: not available
- Details on inhalation exposure:
- no details
- Analytical verification of doses or concentrations:
- not specified
- Details on analytical verification of doses or concentrations:
- not available
- Duration of treatment / exposure:
- 83 weeks (female), 91 weeks (male)
- Frequency of treatment:
- 5 hr/d, 5d/wk
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 1000, 10,000, 50,000 ppm
Basis:
nominal conc.
- No. of animals per sex per dose:
- 80
- Control animals:
- yes
- Details on study design:
- Eighty male and eighty female Alderley Park Swiss mice per group were exposed to concentrations of 0, (two groups) 1000, 10,000 or 50,000 ppm (0, 3500, 35,000, 175,000 mg/m3) chlorodifluoromethane, 5 hr/d, 5 d/wk for up to 83 weeks (females) and 94 weeks (males).
- Positive control:
- not reported
Examinations
- Observations and examinations performed and frequency:
- At week 38, 10 mice per group were killed in order to perform blood and biochemical assays including red and white blood cell measurements, platelet count, prothrombin and kaolin-cephalin clotting times and bone marrow examination. Plasma ALT (alanine transaminase) and AST (aspartate transaminase) activity as well as urine analyses were also undertaken.
- Sacrifice and pathology:
- not details reported
- Other examinations:
- not reported
- Statistics:
- not reported
Results and discussion
Results of examinations
- Clinical signs:
- no effects observed
- Mortality:
- no mortality observed
- Body weight and weight changes:
- no effects observed
- Food consumption and compound intake (if feeding study):
- not examined
- Food efficiency:
- not examined
- Water consumption and compound intake (if drinking water study):
- not examined
- Ophthalmological findings:
- not examined
- Haematological findings:
- no effects observed
- Clinical biochemistry findings:
- no effects observed
- Urinalysis findings:
- no effects observed
- Behaviour (functional findings):
- effects observed, treatment-related
- Description (incidence and severity):
- hyperactivity at 50,000 ppm chrlodifluoromethane
- Organ weight findings including organ / body weight ratios:
- no effects observed
- Gross pathological findings:
- not examined
- Histopathological findings: non-neoplastic:
- no effects observed
- Histopathological findings: neoplastic:
- no effects observed
- Details on results:
- The only consistent finding was hyperactivity in male mice exposed to 50,000 ppm chlorodifluoromethane. No effects were noted on mortality, body weight gain, haematology and biochemistry nor in histopathology. The No Observed Adverse Effect Concentration (NOAEC) for chlorodifluoromethane in this study was 10,000 ppm (35,000 mg/m3).
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- 10 000 ppm
- Based on:
- test mat.
- Sex:
- male/female
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
not available
Applicant's summary and conclusion
- Executive summary:
Eighty male and eighty female Alderley Park Swiss mice per group were exposed to concentrations of 0, (two groups) 1000, 10,000 or 50,000 ppm (0, 3500, 35,000, 175,000 mg/m3) chlorodifluoromethane, 5 hr/d, 5 d/wk for up to 83 weeks (females) and 94 weeks (males). The only consistent finding was hyperactivity in male mice exposed to 50,000 ppm chlorodifluoromethane. No effects were noted on mortality, body weight gain, haematology and biochemistry nor in histopathology. The No Observed Adverse Effect Concentration (NOAEC) for chlorodifluoromethane in this study was 10,000 ppm (35,000 mg/m3).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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