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Diss Factsheets
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EC number: 284-366-9 | CAS number: 84852-53-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Guideline- and GLP-compliant 28- and 90-d studies in rats. Results published in the peer-reviewed literature.
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Dose descriptor:
- NOAEL
- 1 000 mg/kg bw/day
- Study duration:
- subchronic
- Species:
- rat
Additional information
The 28 -day no-observed-effect-level (NOEL) in the Sprague Dawley rat was >= 1,250 mg/kg/d, the highest dose tested, administered by oral gavage in corn oil. The NOEL was based on the absence of toxicity at this dose as measured by: body weight, food consumption, body weight gain, hematology and serum chemistry values, urinalysis, ocular exam, gross necropsy results, organ weight, and light microscopic exam of selected tissues.
The 90 -day no-adverse-effect level (NOAEL) in the Sprague Dawley rat was 1,000 mg/kg/d, the highest dose tested, administered by oral gavage in corn oil. No animals died on test. Clinical signs were non-specific, low in incidence, non-dose-related and not related to test article administration. No test-article-related ocular lesions were detected on ophthalmic exam. Oral dose levels of up to 1000 mg/kg/day for 90 days produced no evidence of systemic toxicity, ocular effects, or treatment-related alterations in urine, serum chemistry and hematology values in rats. No toxic effect was found on body weights, body weight gains or food consumption. The only organ weight affected was liver. Mean liver weights were increased at 1000 mg/kg/day, but not at 320 mg/kg/day, the next lower dose. Low-grade microscopic liver changes accompanied the increase in liver weights in male rats. The liver changes were characterized by minimal to slight hepatocellular vacuolation (high dose males) and minimal to slight centrilobular hepatocytomegaly (high, and possibly mid dose, males), and were considered an adaptive response. No changes were found in the livers of female rats. The liver changes resolved without any delayed or long-term effect after a 28-day recovery period. The no-adverse-effect-level (NOAEL) was 1,000 mg/kg/d, and was confirmed in the UK's review of the study during their assessment of the product.
Justification for classification or non-classification
Non-classification: NOEL in a rat 28 -day study >= 1250 mg/kg/d; NOAEL in a rat 90-day study = 1,000 mg/kg/d.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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