Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 220-688-8 | CAS number: 2867-47-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Referenceopen allclose all
- Reference Type:
- other: summary report
- Title:
- Unnamed
- Year:
- 1 998
- Reference Type:
- publication
- Title:
- Toxicity Testing Reports of Envirmnmental Chemicals vol. 6, p. 539-568
- Author:
- Ministry of Health and Welfare, Japan
- Year:
- 2 003
- Bibliographic source:
- cited in: OECD SIDS, 2-Dimethylaminoethylmethacrylate, CAS No: 2867-47-2, 07/2003
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
Test material
- Reference substance name:
- 2-dimethylaminoethyl methacrylate
- EC Number:
- 220-688-8
- EC Name:
- 2-dimethylaminoethyl methacrylate
- Cas Number:
- 2867-47-2
- Molecular formula:
- C8H15NO2
- IUPAC Name:
- 2-(dimethylamino)ethyl methacrylate
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- TEST MATERIAL:
Name of test material: 2-(dimethylamino)ethyl methacrylate
Test animals
- Species:
- rat
- Strain:
- other: Crj:CD(SD)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Japan Charles River Co., Ltd.
- Age at study initiation:
- Weight at study initiation: 134-152 g (males); 108-125 g (females)
- Fasting period before study: not specified
- Housing: polycarbonate cage (265W x 426D x 200H mm, Tokiwa Scientific Instruments Co., Ltd.) for lab animal bedding (Beta Chip, Nippon Charles River Co., Ltd.)
- Historical data: not specified
- Diet (e.g. ad libitum): autoclave-sterilized lab animal solid feed (MF, Oriental Yeast Co., Ltd.), ad libitum
- Water (e.g. ad libitum): Uv-irraditated tap water filtered through 5 µm filter,ad libitum
- Acclimation period: 7 days
- Microbiological status when known: SPF animals
- Method of randomisation in assigning animals to test and control groups
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22+/-2°C
- Humidity (%): 55+/-15%
- Air changes (per hr): 12
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: To:
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Doses:
- 0 (Vehicle), 500, 1000, 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes - Statistics:
- The weight measurements were tested for homoscedasticity through the Bartlett method, one-way ANOVA for equal variances, and Kruskal-Wallis for unequal variances. If there was a significant difference between the groups, the Dunnet method or Dunnet-type multiple comparison test was performed.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- not determinable due to absence of adverse toxic effects
- Mortality:
- No deaths occurred in any of the treated groups.
- Clinical signs:
- other:
- Body weight:
- other body weight observations
- Remarks:
- Both males and females showed similar transitions compared to the control group.
- Gross pathology:
- Two males in the 2000 mg / kg group had a raised lesion in the anterior stomach. No other abnormalities were found.
- Other findings:
- Examination of the stomachs of two males in the 2000 mg / kg group, which were abnormal at autopsy, revealed mild papillary hyperplasia in the anterior gastric mucosa in one case. No other abnormalities were found.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Executive summary:
2- (Dimethylamino) ethyl methacrylate was orally administered to rats at a dose of 500, 1000 and 2000 mg / kg.
No deaths were observed in any of the groups, and no abnormalities were observed in the general condition or in body weight. Necropsy revealed a raised lesion in the anterior gastric region in males in the 2000 mg / kg group, and histopathologically papillary hyperplasia of the anterior gastric mucosa was observed as a related change. Acrylic acid esters containing this test substance are known to cause acute irritation to mucosa, and it has been reported that oral administration of ethyl acrylate causes hyperplasia of the anterior gastric mucosa in rats 2). Since this change is considered to be the result of a local inflammatory response to the stimulant 2), the change in the anterior stomach observed with this test substance is also considered to be the convergent with the inflammatory response to the stimulus.
The median lethal dose (LD50 value) of a single oral dose of 2- (dimethylamino) ethyl methacrylate to rats was 2000 mg / kg or more for both males and females.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.