Registration Dossier
Registration Dossier
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EC number: 202-981-2 | CAS number: 101-84-8
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Two short-term toxicity studies with Diphenyl Oxide (DPO or Dipheny Ether) were conducted with Daphnia magna following available guidelines at different laboratories. A quantitative structure-activity relationship (QSAR) model was used to estimate the acute toxicity.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 1.96 mg/L
Additional information
One key study was identified that provided acute toxicity test results with Daphnia magna exposed to Diphenyl Oxide (DPO or Diphenyl Ether). This study was rated a Klimisch score of 1 and was considered reliable reporting a 48-hr EC50 value of 1.96 mg/L (95% confidence interval of 1.74 - 2.21 mg/L).
A supporting study was rated a Klimisch score of 1 and was considered reliable reporting a 48-hr LC50 value of 1.7 mg/L.
These results were corroborated by a quantitative structure-activity relationship (QSAR) model (ECOSAR v1.11 by U.S. Environmental Protection Agency, 2012) estimation which shows the 48-hr LC50 of 1.0 mg/L.
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