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EC number: 270-112-4 | CAS number: 68411-27-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 16. Feb. 1979 - 27. Apr. 1979
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- no
- Test type:
- other: trade name
- Limit test:
- yes
Test material
- Reference substance name:
- Benzoic acid, C12-15-alkyl esters
- EC Number:
- 270-112-4
- EC Name:
- Benzoic acid, C12-15-alkyl esters
- Cas Number:
- 68411-27-8
- Molecular formula:
- C19-22 H30-36 O2
- IUPAC Name:
- Benzoic acid, C12-15-alkyl esters
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Summit View Farm, Belvidere, New Jersey
- Weight at study initiation: 200 -246 g
- Diet: Wayne animal feed, ad libitum
- Water: ad libitum
- Acclimation: animals were conditioned prior to use
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: plastic chamber
- Exposure chamber volume: three-cubic-foot
- Source and rate of air: preconditioned supportive air at 5 L/minute
- System of generating particulates/aerosols: Preconditioned supportive air was supplied and the test material was presented from a compressor activated generator or timer operated solenoid to continue a nominal chamber concentration of 200 mg / liter air
TEST ATMOSPHERE
- nominal concentration of 200 mg / liter air
VEHICLE
- Composition of vehicle (if applicable): air
- Concentration of test material in vehicle (if applicable): 200 mg / liter air - Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 1 h
- Concentrations:
- 200 mg / liter air
- No. of animals per sex per dose:
- 5 males, 5 females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: observations daily (1, 3, 6, 24 hours after exposure on day 1) and weighing at start and end of the experiment
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight , necropsy
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 200 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 1 h
- Mortality:
Dose Level (mg/l) Sex # dead /# dosed Mortality ( %)
200 5 M : 5 F 1/5 : 0/5 10- Clinical signs:
- other: Slight depression observed 1 hour after exposure at all 10 animals, otherwise no abnormal clinical signs within 14 days after exposure.
- Body weight:
- Body weight gain at 9 survived animals 14 days after exposure.
Body weight loss at 1 animal that died on 9th day after exposure. - Gross pathology:
- Animal #1: All lobes of right lung enlarges and consolidated. Animal died on day 9.
Animals #2 - #10: No gross changes observed.
Any other information on results incl. tables
Dose (mg/l |
Animal No. and Sex |
Body weight (g) |
Hours:
1 3 6 24 |
Days:
2 3 4 5 6 7 --14 |
Body weight (g) |
||||||||
200 |
1 M |
202 |
SD |
N |
N |
N |
N |
N |
N |
N |
N |
N+ - |
156 |
200 |
2 M |
230 |
SD |
N |
N |
N |
N |
N |
N |
N |
N |
N N |
296 |
200 |
3 M |
232 |
SD |
N |
N |
N |
N |
N |
N |
N |
N |
N N |
324 |
200 |
4 M |
230 |
SD |
N |
N |
N |
N |
N |
N |
N |
N |
N N |
290 |
200 |
5 M |
246 |
SD |
N |
N |
N |
N |
N |
N |
N |
N |
N N |
312 |
200 |
6 F |
204 |
SD |
N |
N |
N |
N |
N |
N |
N |
N |
N N |
222 |
200 |
7 F |
200 |
SD |
N |
N |
N |
N |
N |
N |
N |
N |
N N |
226 |
200 |
8 F |
200 |
SD |
N |
N |
N |
N |
N |
N |
N |
N |
N N |
262 |
200 |
9 F |
200 |
SD |
N |
N |
N |
N |
N |
N |
N |
N |
N N |
210 |
200 |
10 F |
200 |
SD |
N |
N |
N |
N |
N |
N |
N |
N |
N N |
220 |
N = Normal
SD = Slight Depression
+ = Animal Death
Animal No. 1: All lobes of right lung enlarges and consolidated; died on day 9.
Animal No. 2-10: No gross changes observed.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In the Acute Inhalation Toxicity study on Wistar-derived rats the LC50 of the test material was determined as being > 200 mg/l.
There was a 10% mortality observed in the exposed rats. Under the conditions if this study the test material is considered to be not toxic by inhalation to rats. - Executive summary:
In an Acute Inhalation Toxicity study ten albino rats (5M:5F, 200 -246 g body weight) were exposed to concentrations of 200 mg test material / liter air for 1 hour and observed for two weeks. Mortality, clinical signs and body weight development were monitored during the study. All animals were subjected to gross necropsy.
Mortality: 10 % (1/10 animals)
Clinical Observations: Slight depression was observed at all animals 1 h after exposure; otherwise no abnormal clinical signs within 14 days observation period.
Body weight: Body weight gain at 9 animals after the 14 days observation period, body weight loss at 1 animal that died after exposure.
Necropsy: No gross changes observed at 9 animals. In the one dead animal all lobes of right lung enlarges and consolidated.
Conclusion: The LC50 of the test material was determined as being > 200 mg/l. Under the conditions if this study the test material is considered to be not toxic by inhalation.
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