Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-423-8 | CAS number: 95-48-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Endpoint summary
Administrative data
Description of key information
There is no study according to the current OECD test guideline but the studies, which were choses as key studies, are adequately documented and are considered of sufficient quality to allow an evaluation of this endpoint. Based on the results in these studies o-cresol is evaluated as corrosive.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: sufficient information for evaluation
- Principles of method if other than guideline:
- Application of the undiluted substance on shaved intact or abraded skin areas, coverage not mentioned, reading 24,48, 72 hours.
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- no further information
- Type of coverage:
- not specified
- Preparation of test site:
- other: shaved : intact and abraded
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 0.5 ml
- Duration of treatment / exposure:
- no data
- Observation period:
- 72 hours
- Number of animals:
- 6
- Details on study design:
- Evaluation of erythema and edema.
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- ca. 4
- Max. score:
- 4
- Reversibility:
- no data
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- ca. 4
- Max. score:
- 4
- Reversibility:
- no data
- Irritation parameter:
- overall irritation score
- Basis:
- other: mean value overall animals
- Time point:
- other: abraded and intacxt skin: after 72 hours
- Score:
- ca. 8
- Max. score:
- 8
- Reversibility:
- no data
- Irritant / corrosive response data:
- no further information
- Other effects:
- no further information
- Interpretation of results:
- Category 1 (corrosive) based on GHS criteria
- Executive summary:
Application of 0.5 ml undiluted substance on shaved intact or abraded rabbit skin areas, coverage not mentioned, and reading 24, 48, 72 hours post application yielded mean irritation score: 8 of max 8. Reversibility is not reported (Industrial Biotest Laboratories 1969).
Reference
intact and abraded skin:
total irritation score: 8.00/8.00
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: sufficient information to evaluate the substance
- Principles of method if other than guideline:
- Application of 0.1 ml of the undiluted substance into the eye of each of 6 rabbits reading 24hrs, 48 hrs and 72 hours: cornea, iris, conjunctivae.
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- no further information
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: the second eye served as control
- Amount / concentration applied:
- undiluted
Amount applied: 0.1 ml - Duration of treatment / exposure:
- no data
- Observation period (in vivo):
- up to 72 hours
- Number of animals or in vitro replicates:
- 6
- Details on study design:
- Comment: no data
- Irritation parameter:
- other: cornea score, iris score, conjunctivae score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- ca. 91.3
- Max. score:
- 110
- Irritation parameter:
- other: cornea score, iris score, conjunctivae score
- Basis:
- mean
- Time point:
- 48 h
- Score:
- ca. 86.3
- Max. score:
- 110
- Irritation parameter:
- other: cornea score, iris score, conjunctivae score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- ca. 82.7
- Max. score:
- 110
- Reversibility:
- not specified
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: after 72 hour reading
- Score:
- ca. 91.3
- Max. score:
- 110
- Reversibility:
- not reversible
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Reversibility:
- not specified
- Remarks on result:
- other: no data for edema score avaiable. Total irritation score: 91.3/110
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Reversibility:
- not specified
- Remarks on result:
- other: no data for iris score avaiable. Total irritation score: 91.3/110
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Reversibility:
- not specified
- Remarks on result:
- other: no data for conjunctivae score avaiable. Total irritation score: 91.3/110
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Reversibility:
- not specified
- Remarks on result:
- other: no data for chemosis score avaiable. Total irritation score: 91.3/110
- Irritant / corrosive response data:
- no further data
- Other effects:
- none reported
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Executive summary:
Application of 0.1 ml undiluted testsubstance into the eyes of rabbits and observation for up to 72 hours resutlted into a mean score of 97 of max 110. Reversibility is not reported (Industrial Biotest Laboratories 1969).
Reference
Total irritation score: 91.3/110.
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
There is no study according to the current OECD test guideline but the studies, which were choses as key studies, are adequately documented and are considered of sufficient quality to allow an evaluation of this endpoint.
SKIN
Undiluted o-cresol was applied to the intact and abraded skin of rabbits (no further experimental details given) and caused within 24 hours severe erythema and edema in each rabbit (mean score 8.00 of 8.00 [max], Ind. Bio-test Lab Inc 1969). In another study, application of o-cresol for 4 hours under semiocclusive conditions yielded severe edema and necrosis within 24 hours and eschar formation within 14 days (no scores given, Ferro Corp 1978).
EYE
Application of o-cresol into the conjunctival sac of the rabbits eyes resulted in severe irritation (mean score: 91.3 of 110[max]). Recovery was not reported (Ind. Bio-test Lab Inc 1969).
OVERALL
Based on the results in these studies o-cresol is evaluated as corrosive.
Effects on skin irritation/corrosion: corrosive
Effects on eye irritation: corrosive
Justification for classification or non-classification
Under Harmonised classification - Annex VI of Regulation (EC) No 1272/2008 (CLP Regulation) - m-and p-cresol as well as o-cresol are classified as corrosive Skin Corr. 1B; H314.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)