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Diss Factsheets
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EC number: 200-909-4 | CAS number: 75-86-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- chronic toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
- Principles of method if other than guideline:
- Method: Similar to OECD.
- GLP compliance:
- yes
- Limit test:
- no
Test material
- Reference substance name:
- 2-hydroxy-2-methylpropionitrile
- EC Number:
- 200-909-4
- EC Name:
- 2-hydroxy-2-methylpropionitrile
- Cas Number:
- 75-86-5
- Molecular formula:
- C4H7NO
- IUPAC Name:
- 2-hydroxy-2-methylpropanenitrile
- Details on test material:
- - Name of test material (as cited in study report): Acetone Cyanohydrin
- Physical state: liquid
- Analytical purity: 98.5 %
- Purity throughout the test: 98.13 to 97.79 %
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Laboratory, USA, Crl:CD(SD)BR
- Age at study initiation: males: 49 days and females: 54 days of age
- Weight at study initiation: males: 215 - 235 g and females 170 to 189 g
- Fasting period before study: no data
- Housing: individual, all wire, inhalation-type rat cages
- Diet: ad libitum except during the exposure periods
- Water: tap water, ad libitum except during the exposure periods
- Acclimation period: minimum 10 days
ENVIRONMENTAL CONDITIONS
- Temperature (°F): 72 ±2°F
- Humidity (%): 35 - 60 %
- Air changes (per hr): 8 to 15 chamber volumes per hour
- Photoperiod: 12 hrs dark/ 12 hrs light
Administration / exposure
- Route of administration:
- inhalation
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: 10 m³ Rochester-type stainless steel chambers with pyramidal tops and bottoms - Analytical verification of doses or concentrations:
- yes
- Details on analytical verification of doses or concentrations:
- The infrared method was used to verify the test concentrations containing acetone cyanohydrin in air. Concentrations to be measured are over a range of 5 ppm to 70 ppm in air.
- Duration of treatment / exposure:
- 98 days
- Frequency of treatment:
- 6 hrs/day 5 days/week
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 10.1 (± 0.91 S.D.), 28.6 (± 1.8 S.D.), and 57.7 (± 2.9 S.D.) ppm
Basis:
analytical conc.
- No. of animals per sex per dose:
- 15 male and 15 female rats per dose group
- Control animals:
- yes, concurrent no treatment
Results and discussion
Results of examinations
- Clinical signs:
- no effects observed
- Mortality:
- no mortality observed
- Body weight and weight changes:
- no effects observed
- Description (incidence and severity):
- no changes in mean body weights
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- 57.7 ppm
- Based on:
- test mat.
- Sex:
- male/female
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Under the conditions tested in this study a NOEL for toxicity other than irritation and breathing difficulties was established to be 57.7ppm (highest
test concentration) for Acetone cyanohydrin. - Executive summary:
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