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Diss Factsheets
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EC number: 619-079-3 | CAS number: 949109-75-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to a scientifically acceptable protocol, and in compliance with GLP. There was limited information on the purity of the test substance.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
- Report date:
- 1994
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 16 CFR 1500.3
- Principles of method if other than guideline:
- To determine the dermal corrosivity and primary dermal irritation, if any, when Generol 122 is applied to the skin of albino rabbits. On the day prior to dosing, the dorsal surface of each rabbit was clipped free of fur using electic clippers, with care taken to avoid accidental abrasion to the skin. A volume of 0.5 ml of test article was applied to each of the three sites per rabbit. The test sites were divided into one front site and two back sites separated by the spinal column. Prior to the application of the test substance the site on the right back side was abraded with the tip of a hypodermic needle. The abrasions were four incisions made in a cross hatch which oenetrated the stratum corneum but did not cause bleeding or disturb the dermis. Following application, each test site was occluded with a 1 inch square gauze patch held in place with tape and wrapped with an occlusive binder in accordance with FDRL Standard Operating Procedures.
- GLP compliance:
- yes
Test material
- Reference substance name:
- Not applicable-UVCB
- EC Number:
- 619-079-3
- Cas Number:
- 949109-75-5
- Molecular formula:
- UVCB- Mixture of many formulae.
- IUPAC Name:
- Not applicable-UVCB
- Test material form:
- other: Liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 48 hours
- Number of animals:
- 6
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 4 and 48 hours
- Score:
- 0
- Max. score:
- 6
- Reversibility:
- other: Not irritating
- Remarks on result:
- other: Not irritating
- Other effects:
- No erythema, eschar formation or oedema was noted in any of the animals at the 4 and 48 hour observation periods. The mean primary skin irritation score (FHSA) is 0.00 Therefore, according to 16CFR 1500.3 Generol 122 is not considered to be a primary skin irritant.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: other: FHSA
- Conclusions:
- On the basis that no erythema or other effects were reported in the duration of the study it can be concluded that Generol 122 is not considered to be corrosive or irritating to the skin of rabbits.
- Executive summary:
In a well conducted skin irritation study in rabbits, no erythema was noted in any of the test animals at the 4 and 48 hour observation periods. The mean primary skin irritation score (FHSA) is 0.00 Therefore, according to USA 16CFR 1500.3 the test substance is not considered to be irritating to skin.
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