Registration Dossier
Registration Dossier
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EC number: 201-279-3 | CAS number: 80-43-3
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Publication in peer reviewed journal. However, limited information is given on exposure situation (no direct measurements of the test substance). Only 18 workers were investigated.
Data source
Reference
- Reference Type:
- publication
- Title:
- Formation of new blood vessels in the nose after exposure to dicumylperoxide at a chemical plant.
- Author:
- Petruson B, Järvholm B
- Year:
- 1 983
- Bibliographic source:
- Acta Otolaryngol 95, 333-339
Materials and methods
- Study type:
- other: Investigation of worker at a chemical plant
- Endpoint addressed:
- respiratory irritation
- Principles of method if other than guideline:
- No guideline available
Test material
- Reference substance name:
- Bis(α,α-dimethylbenzyl) peroxide
- EC Number:
- 201-279-3
- EC Name:
- Bis(α,α-dimethylbenzyl) peroxide
- Cas Number:
- 80-43-3
- Molecular formula:
- C18H22O2
- IUPAC Name:
- 1,1'-(dioxydipropane-2,2-diyl)dibenzene
- Details on test material:
- No further information given, only named as dicumylperoxide
Constituent 1
Method
- Type of population:
- occupational
- Subjects:
- 18 workers, mean age 43, smokers 7, mean exposure time 3.3
- Ethical approval:
- not specified
- Route of exposure:
- inhalation
- Reason of exposure:
- unintentional, occupational
- Exposure assessment:
- not specified
- Details on exposure:
- only dust was measured: 0.9 mg/m3 during routine work, 2 samples when cleaning a sieve were reported to be 49 and 5.5 mg/m3
- Examinations:
- Questionaire, rhinoscopy, mucociliary function, Rhinomanometry
Results and discussion
- Clinical signs:
- The mucociliary function and nasal airflow were the same in exposed and unexposed subjects. 9 workers exposed to the test substance had visible blood vessels in the muscosa of the anterior part of nasal septum, while only 2 persons in the control group had such effects. Both subjects had a cold at the time of teh examination.
Applicant's summary and conclusion
- Conclusions:
- The study revealed visible blood vessels in the nasal mucosa. The authors discussed that DCP may have contributed to the formation of blood vessels. Given the fact that only a limited number of worker were investigated and the exposure was not measured, the reliability was rated as not assignable.
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