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EC number: 246-836-1 | CAS number: 25321-14-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards, well documented and acceptable for assessment
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Pathological excretion patterns of urinary proteins in miners highly exposed to dinitrotoluene.
- Author:
- Bruening, T. et al.
- Year:
- 2 001
- Bibliographic source:
- J. Occup. Environ. Med. 43, 610-615.
- Reference Type:
- secondary source
- Title:
- Nephrotoxicity and nephrocarcinogenicity of dinitrotoluene : New aspects to be considered.
- Author:
- Bruening, T. et al.
- Year:
- 2 002
- Bibliographic source:
- Reviews on Environmental Health 17, 163- 172.
- Reference Type:
- secondary source
- Title:
- Dinitrotoluene (isomers mixture), CAS No.: 25321-14-6
- Author:
- OECD SIDS
- Year:
- 2 004
Materials and methods
- Type of study / information:
- Health records
- Principles of method if other than guideline:
- A cohort of 161 underground miners who had been highly exposed to DNT in copper-mining industry of former German Democratic Republic was reinvestigated for signs of subclinical renal damage.
- GLP compliance:
- no
Test material
- Reference substance name:
- Dinitrotoluene
- EC Number:
- 246-836-1
- EC Name:
- Dinitrotoluene
- Cas Number:
- 25321-14-6
- Molecular formula:
- C7H6N2O4
- IUPAC Name:
- Reaction mass of 1-methyl-2,4-dinitrobenzene and 2-methyl-1,3-dinitrobenzene
- Details on test material:
- - Name of test material (as cited in study report): 30% technical DNT (about 80% 2,4-DNT and 20% 2,6-DNT);
- Composition of test material, percentage of components: 30% , the composition of the remaining 70% of the explosives is not given
- Purity test date: no data
Constituent 1
Method
- Details on study design:
- 161 representative underground miners, that had all been highly exposed to DNT, and 19 miners with renal or urothelial cancer formerly highly exposed to explosives containing technical DNT out of a total group of 3000 underground miners in a plant in the former German Democratic Republic were reinvestigated for signs of subclinical renal damage. Studied parameters were alpha1-microglobulin and GST alpha as biomarkers for damage of the proximal tubule and GST pi for damage of the distal tubule.
The miners were grouped into 4 exposure categories according to types and duration of contact to DNT: skin contact (at least 5 hours per day) and inhalative exposure (no quantitative data; semi-quantitative procedure). - Exposure assessment:
- estimated
Results and discussion
- Results:
- Results indicated a dose-dependent nephrotoxic effect directed to the tubular system with an increased incidence in renal or urothelial cancer cases (n=19) in contrast to the group of representative miners without cancer (n=161).
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.