Registration Dossier
Registration Dossier
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EC number: 938-945-4 | CAS number: -
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
The substance exhibits an ErC50 for freshwater algae of 5.4 mg/L.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 5.4 mg/L
- EC10 or NOEC for freshwater algae:
- 3.47 mg/L
Additional information
The submission substance contains many constituents making the analytical monitoring very difficult for the purposes of environment and ecotoxicological testing.
One reliable study is available for the registered substance. The toxicity to aquatic algae was studied by following the OECD TG No. 201 and OECD Guidance document No. 23 on aquatic toxicity testing of difficult substances and mixtures, under GLP. Algae cultures (Pseudokirchneriella subcapitata) were exposed to Water-accommodated fraction (WAF) of the substance at loading rates of 1.0, 1.6, 2.5, 4.0, 6.3 and 10 mg/L over a test period of 72 hours (static test). The fraction of the multi-constituent substance present in test medium with and without algae were monitored daily; for this purpose, all the chromatographic peaks areas were summed as surrogate of a concentration for the multi-constituent substance. The overall measured concentrations, as total peak area, deviated more than 20% of the initial concentrations. However, test data obtained with WAF Methodology apply for the multi-constituent substance. Such WAF data are proposed for use to assess the aquatic toxicity of multi-component substance in GHS / CLP. The endpoints were based on loading rates. Based on the loading rates and under the experimental conditions, the 72 -hour EC50 for growth rate was determined to 5.4 mg/L and the 72 -hour EC10 to 3.47 mg/L.
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