Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-712-3 | CAS number: 69-72-7
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation
- Remarks:
- other: Statistical analysis
- Type of information:
- other: Statistical evaluation
- Adequacy of study:
- supporting study
- Study period:
- not applicable
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Data which do not give sufficient experimental details and which are only listed in this publication. No data on purity.
Data source
Reference
- Reference Type:
- publication
- Title:
- Threshold for classification as a skin sensitizer in the local lymph node assay: a statistical evaluation.
- Author:
- Basketter DA, Lea LJ, Cooper K et al
- Year:
- 1 999
- Bibliographic source:
- Food and Chemical Toxicology, 37, 1167-1174
Materials and methods
Test guideline
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- Statistical analysis of data from LLNA, guinea pig maximisation/Buehler test and human data.
- GLP compliance:
- not specified
- Type of study:
- other: Statistical analysis of LLNA and GPMT/BT
Test material
- Reference substance name:
- Salicylic acid
- EC Number:
- 200-712-3
- EC Name:
- Salicylic acid
- Cas Number:
- 69-72-7
- Molecular formula:
- C7H6O3
- IUPAC Name:
- 2-hydroxybenzoic acid
- Details on test material:
- Test substance: salicylic acid
no other information
Constituent 1
In vivo test system
Test animals
- Species:
- other: mouse and guinea pig
Results and discussion
Any other information on results incl. tables
Results for salicylic acid (concentration
not stated) :
LLNA : negative (Stimulation Indice < 3)
Guinea pig maximisation test: negative
Human data: negative
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Classification: not sensitizing
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
