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EC number: 262-679-1 | CAS number: 61260-55-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 15 Jan 1985 - 24 Jan 1985
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- adopted May 12, 1981
- Deviations:
- no
- GLP compliance:
- not specified
Test material
- Reference substance name:
- N,N'-bis(2,2,6,6-tetramethylpiperidin-4-yl)hexane-1,6-diamine
- EC Number:
- 262-679-1
- EC Name:
- N,N'-bis(2,2,6,6-tetramethylpiperidin-4-yl)hexane-1,6-diamine
- Cas Number:
- 61260-55-7
- Molecular formula:
- C24H50N4
- IUPAC Name:
- N1,N6-bis(2,2,6,6-tetramethylpiperidin-4-yl)hexane-1,6-diamine
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: Kleinrussen Chbb-SPF
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Fa. Dr. Karl Thomae GmbH, Biberach
- Weight at study initiation: 2.1-2.5 kg
- Housing: individually in stainless steel cages
- Diet (ad libitum): K4 Alleindiät for rabbits, Ssniff Spezialfutter GmbH, 4770 Soest, ad libitum
- Water (ad libitum): tap water ad libitum
- Acclimation period: 14 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 ± 1
- Humidity (%): 60 ± 5
- Air changes (per hr): 15
- Photoperiod (hrs dark / hrs light): 12 / 12
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- other: paraffin oil for humidification
- Controls:
- other: the untreated sites of the same animal served as control
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied: 0.5 g - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 72 hours
- Number of animals:
- 6 (3 males and 3 females)
- Details on study design:
- TEST SITE
- Area of exposure: 6 cm²
- Type of wrap if used: polyethylene foil with an elastic bandage
REMOVAL OF TEST SUBSTANCE
- Washing: rinsed with warm water
- Time after start of exposure: 4 hours
SCORING SYSTEM: according to Draize
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal: #1-6
- Time point:
- other: mean over 24, 48, 72 hours
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- edema score
- Basis:
- animal: #1-4
- Time point:
- other: mean over 24, 48, 72 hours
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- edema score
- Basis:
- animal #5
- Time point:
- other: mean over 24, 48, 72 hours
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- edema score
- Basis:
- animal #6
- Time point:
- other: mean over 24, 48, 72 hours
- Score:
- 3.7
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritant / corrosive response data:
- Test substance showed severe irritating effects on male and female rabbit skin. Necrosis (full thickness) appeared after 4 hours, but not after 3 minutes. See also Table 1 (Any other information on results)
Any other information on results incl. tables
Table 1. Evaluation of sin reactions, individual scores (Draize) and observations.
Animal # |
Sex |
Reading time point post-exposure |
|||||||
1h |
24 h |
48 h |
72 h |
||||||
Erythema |
Edema |
Erythema |
Edema |
Erythema |
Edema |
Erythema |
Edema |
||
1 |
M |
4 (1) |
4 |
4 (1) |
4 |
4 (2,3,4) |
4 |
4 (1,4,5) |
4 |
2 |
M |
4 (1) |
2 |
4 (1) |
4 |
4 (1,3,4) |
4 |
4 (1,5) |
4 |
3 |
M |
4 (1) |
3 |
4 (1) |
4 |
4 (1) |
4 |
4 (1,5) |
4 |
4 |
F |
4 (1,2) |
4 |
4 (1) |
4 |
4 (1,3,4) |
4 |
4 (1,4,5) |
4 |
5 |
F |
4 (1, 2) |
3 |
4 (1) |
2 |
4 (1,3,4) |
4 |
4 (1,4,5) |
4 |
6 |
F |
4 (1) |
4 |
4 (1) |
4 |
4 (1) |
4 |
4 (1,5) |
3 |
1: Bloody necrosis and strong green colour
2: Necrosis, green colour at the edges of the application site
3: Application site hardened
4: Deep wounds
5: Scab
Applicant's summary and conclusion
- Interpretation of results:
- Category 1C (corrosive) based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- Under the experimental conditions described, the test substance fulfils the GHS criteria for classification as corrosive (Category 1C).
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