Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-486-1 | CAS number: 96-18-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- other: data from database
- Adequacy of study:
- weight of evidence
- Study period:
- no data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The National Institute of Technology and Evaluation (NITE) is referring to the CRC Handbook 84th ed. A reliability code of 2 is assigned to data from recognized reference handbooks / data collections.
- Reason / purpose for cross-reference:
- reference to other study
- Guideline:
- other: no data
- GLP compliance:
- not specified
- Type of method:
- other: no data
- Water solubility:
- 0.2 vol%
- Temp.:
- 25 °C
- pH:
- > 0 - < 14
- Conclusions:
- Interpretation of results (migrated information): slightly soluble (0.1-100 mg/L)
1,2,3-Trichloropropane has a water solubility of 0.2% (2000 mg/l) at 25 °C. The test item therefore is regarded as "slightly soluble". - Executive summary:
The National Institute of Technology and Evaluatuion (NITE, Japan) is referring to the CRC Handbook 84th ed. A reliability code of 2 is assigned to data. 1,2,3-Trichloropropane has a water solubility of 0.2% (2000 mg/l) at 25 °C. The test item therefore is regarded as "slightly soluble".
- Endpoint:
- water solubility
- Type of information:
- other: data from data base
- Adequacy of study:
- weight of evidence
- Study period:
- no data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The 2004 SIDS dossier is referring to the IUPAC-NIST Solubility Database. A reliability code of 2 is assigned to data from recognized reference handbooks / collection of data.
- Guideline:
- other: no data
- Principles of method if other than guideline:
- Data taken from database, no details on methodology given.
- GLP compliance:
- not specified
- Type of method:
- other: Data taken from database, no details on methodology given.
- Water solubility:
- 1 880 mg/L
- Temp.:
- 20 °C
- pH:
- >= 0 - <= 14
- Water solubility:
- 2 010 mg/L
- Temp.:
- 25 °C
- pH:
- >= 0 - <= 14
- Conclusions:
- Interpretation of results (migrated information): slightly soluble (0.1-100 mg/L)
1,2,3-Trichloropropane has a water solubility of 1880 mg/l at 20 °C. The test item therefore is regarded as "slightly soluble". - Executive summary:
The 2004 SIDS dossier is referring to the water solubility data given in the IUPAC-NIST Solubility Database. The IUPAC-NIST Solubility Database itself uses the average water solubilities reported by three different studies. Based on this, 1,2,3-Trichloropropane has a water solubility of 1880 mg/l at 20 °C. The test item therefore is regarded as "slightly soluble".
- Endpoint:
- water solubility
- Type of information:
- other: data from database
- Adequacy of study:
- weight of evidence
- Study period:
- no data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The 2004 SIDS dossier is referring to a study of Albanese (1987) on the determination of water solubility on 1,2,3-Trichloropropane. In the SIDS dossier a Klimisch-4-rating is given for this study. However, the "Hazardous Substances Data Bank" of the National Library of Medicine is a database referring to the same study of Albanese as "peer reviewed". Therefore all in all a Klimisch-2-score deems to be justified.
- Guideline:
- other: no data
- Principles of method if other than guideline:
- Data taken from database, no details on methodology given.
- GLP compliance:
- not specified
- Type of method:
- other: no data
- Water solubility:
- 1 750 mg/L
- Temp.:
- 25 °C
- pH:
- >= 0 - <= 14
- Conclusions:
- Interpretation of results (migrated information): slightly soluble (0.1-100 mg/L)
1,2,3-Trichloropropane has a water solubility of 1750 mg/l at 25 °C. The test item therefore is regarded as "slightly soluble". - Executive summary:
The 2004 SIDS dossier is referring to the water solubility data given by a study of Albanese 1987. The "Hazardous Substances Data Bank" of the National Library of Medicine is a database referring to the same study of Albanese as "peer reviewed", thus a Klimisch-2 -score was applied. According to Albanese, 1,2,3-Trichloropropane has a water solubility of 1750 mg/l at 25 °C. The test item therefore is regarded as "slightly soluble".
- Endpoint:
- water solubility
- Type of information:
- other: data for handbook
- Adequacy of study:
- weight of evidence
- Study period:
- no data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The 2004 SIDS dossier is referring to handbook data. A reliability code of 2 is assigned to data from recognized reference handbooks.
- Guideline:
- other: no data
- Type of method:
- other: no data
- Water solubility:
- 1 750 mg/L
- Temp.:
- 20 °C
- pH:
- >= 0 - <= 14
- Conclusions:
- Interpretation of results (migrated information): slightly soluble (0.1-100 mg/L)
1,2,3-Trichloropropane has a water solubility of 1750 mg/l at 20 °C. The test item therefore is regarded as "slightly soluble". - Executive summary:
The 2004 SIDS dossier is referring to handbook data of Riddick 1986. The Klimisch score is 2. According to Riddick, 1,2,3-Trichloropropane has a water solubility of 1750 mg/l at 20 °C. The test item therefore is regarded as "slightly soluble".
Referenceopen allclose all
No details given on the pH during the emasurement. It is assumed that the emasurement was done within around the neutral pH range.
No details given on the pH during the measurement. It is assumed that the measurement was done approximately at neutral pH.
No details given on the pH during the measurement. It is assumed that the measurement was done within around the neutral pH range.
No details given on the pH during the measurement. It is assumed that the measurement was done within around the neutral pH range.
Description of key information
Based on a weight of evidence approach, 1,2,3-Trichloropropane has a water solubility of 1880 mg/l at 20 °C and of 2010 mg/l at 25 °C.
Key value for chemical safety assessment
- Water solubility:
- 1 880 mg/L
- at the temperature of:
- 20 °C
Additional information
Compilation of water solubility data on 1,2,3 -Trichloropropane
Data source | Water solubility in mg/l | Temperature °C |
SIDS dossier 2004 / IUPAC-NIST Solubility Database | 1880 |
20 |
SIDS dossier 2004 / IUPAC-NIST Solubility Database |
2010 |
25 |
SIDS dossier 2004 / Albanese 1987 |
1750 |
25 |
SIDS dossier 2004 / Riddick 1986 |
1750 |
20 |
NITE 2009 / CRC Handbook 84th ed. | 2000 | 25 |
The water solubility data reported on 1,2,3 -Trichloropropane are quite consistent (see above table) and the data set therefore considered as robust (all data Klimisch 2). Highlighted are the values 1880 mg/l at 20 °C and 2010 mg/l at 25 °C, as taken from the IUPAC-NIST Solubility Database, and as suggested in the 2004 SIDS dossier.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.