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Diss Factsheets
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EC number: 931-037-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Short description of key information on bioaccumulation potential result:
An assessment of the toxicokinetic behaviour of the substance was made from the available information.
Key value for chemical safety assessment
Additional information
Barium di(bistridecylsulphosuccinate) in mixture with barium hydrogen phosphate is a high molecular weight solid. It has a melting point of 229 °C and decomposes. The estimated boiling point is calculated as >360 °C.
The substance has low water solubility (<21.2 mg/L) and a calculated log Pow of 9.01. Because of the low solubility in water, hydrolysis as a function of pH was not determined. Less than 0.1% of the substance had particle sizes of <100µm, thus the substance is not inhalable.
The substance is not classifiable on grounds of acute toxicity. The study on dermal toxicity revealed significant irritation, but the skin irritancy study suggested that the substance is not classifiable as a skin irritant. It is not an eye irritant. The substance was negative in both a bacterial point mutation assay and an in vitro chromosomal aberrations assay for genotoxicity.
In a 28 day repeated oral dose study, male and female rats received 0, 15, 150 or 350 mg/kg bw/d substance orally, by gavage, as a suspension. Although there were effects seen at 150 and 250 mg/kg bw/d these were considered to represent adaptive changes (to the liver) rather than toxic effects. The no effect level was 15 mg/kg bw/d and the no observed adverse effect level was considered to be 250 mg/kg bw/d.
Absorption
The particle size information indicates that material is unlikely to be inhaled,.
The very low water solubility and very high Log Pow suggest that oral or dermal absorptionof the substancethrough intact gastro-intestinal tract or skin is unlikely to be significant. However, the results of dermal acute toxicity study in rat suggest that, at high concentrations, the substance may be irritating, and possibly corrosive if present in sufficient concentration. The results of the 28 day repeated dose oral study suggest that an adaptive change is taking place in the liver, thus absorption of some kind may have occur. Perhaps some material is hydrolysed to yield absorbable material capable of causing liver vacuolation. It was noted that water solubility for barium increased with increased loading of the water, ascribed to decreased pH.
Distribution
In the unlikely event of intact material being absorbed it is likely to accumulate in fatty tissues.
Metabolism
In the unlikely event of absorption of intact material then some hydrolysis might occur, and sulphate, succinate, phosphate and barium enter their respective metabolic pools.
Excretion
It is unlikely that unchanged material will be excreted. However, the surfactant properties of the substance may also be carried into breakdown products such as sulphosuccinates and these might be included into micelles that appear in the bile and eventually are excreted in the faeces. Many of the possible end metabolic products are likely to appear in urine.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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