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EC number: 234-975-0 | CAS number: 12047-27-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2012
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Barium titanium trioxide
- EC Number:
- 234-975-0
- EC Name:
- Barium titanium trioxide
- Cas Number:
- 12047-27-7
- Molecular formula:
- Ba.O3Ti
- IUPAC Name:
- titanium(4+) barium(2+) trioxidandiide
- Details on test material:
- Test item name : Barium titanate milled ABT-O-21
Other names or
synonyms
: Barium titanate
Lot No. : 33HF-201
Product Code : 1326122
Index No. : 056-002-00-7
CAS No. : 12047-27-7
EINECS No. : 234-975-0
Quantity : 1 kg
Date of manufacture : 2011
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- Age / Body weight Young adult / Body weight: 3.4-3.7 kg
Sex: Female
Number: 3
Housing Condition: Conventional rabbit cage system
Temperature: 18 – 22 oC
Humidity: 30 - 70%
Food: Altromin Maintenance Diet #2123 Fortified
Water: Tap water
The test animals were acclimatised for at least 5 days before the test
was conducted
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- 0.1 g
- Duration of treatment / exposure:
- 0.1 g of test substance was placed in the conjunctival sac of right eye of each animal.
The test substance was removed by rinsing with saline after 1-hour administration.
Dose interval Single dose - Observation period (in vivo):
- Observation of both eyes of each animal was conducted at approximately 1hr, 24,
48 and 72 hrs after test substance application - Number of animals or in vitro replicates:
- 3
- Details on study design:
- The test substance was removed by rinsing with saline after 1-hour administration.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 1 hr
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 1 hr
- Score:
- 0
- Max. score:
- 2
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 1 hr
- Score:
- 1
- Max. score:
- 3
- Reversibility:
- fully reversible within: 24hr
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 1 hr
- Score:
- 0
- Max. score:
- 4
- Other effects:
- No other adverse effect was observed in all the test animals during the observation
period.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Based on the above result barium titanate milled ABT-O-21, Lot No: 33HF-201 does not require classification as an eye irritant.
- Executive summary:
Both eyes of the animal were examined and scored at 1 hr, 24 hrs, 48 hrs and 72 hrs after administration:
- At any time during the observation period, no severe eye lesions or continuing signs of severe pain or distress was observed in all the three animals;
- Some blood vessels hyperaemic (injected) in conjunctivae (score at 1) was observed in the right (test) eye in 219149115-02-00-1, 219149115-02-00-2 and 219149115-02-00-3 at 1 hour after administration;
- No ocular reaction was observed in both eyes of all the three animals at 24 hr, 48 hr and 72 hr after administration; 9.4 No other adverse effect was observed in all the three animals during the observation period.
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