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EC number: 221-921-6 | CAS number: 3282-30-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Principles of method if other than guideline:
- other
- GLP compliance:
- yes
Test material
- Reference substance name:
- Pivaloyl chloride
- EC Number:
- 221-921-6
- EC Name:
- Pivaloyl chloride
- Cas Number:
- 3282-30-2
- Molecular formula:
- C5H9ClO
- IUPAC Name:
- 2,2-dimethylpropanoyl chloride
- Details on test material:
- Purity of test material was not analytically confirmed. It was used as received from PPG Industries. Purity of that material is listed as > 99% on the MSDS.
Constituent 1
Test animals / tissue source
- Species:
- rabbit
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.1 mL
- Duration of treatment / exposure:
- Three of the nine treated eyes were each washed with room temperature deionized water 30 seconds after treatment.
- Observation period (in vivo):
- 21 days
- Number of animals or in vitro replicates:
- 9 (eyes of 3 animals were washed after 30 s)
- Details on study design:
- A test with fluorescein showed that the eyes were normal prior to testing. Test material (0.1 ml) was placed into the conjunctival sac of the right eye of each of 9 animals. The lids were held together for one second. Three of the nine treated eyes were each washed with room temperature deionized water for 1 minute, 30 seconds after treatment.
The untreated left eye served as a control.
The treated eyes were examined for irritation 1, 24, 48 hours and 4, 7, 10, 14, 17 and 21 days after treatment. The corneas were re-examined after treatment with 0.2% fluorescein sodium ophthalmic solution after the 24 hour observation time. If staining was observed, staining was repeated after each subsequent evaluation time until staining no longer occurred.
Eyes were scored on scales of 0-4 for corneal opacity, area of cornea involved, fluorescein staining, corneal stippling, and conjunctival chemosis; a scale of 0-2 for iridial effects, scales of 0-3 for conjunctival redness and discharge, for total maximum corneal, iridial and conjunctival scores of 80, 10 and 20 (total maximum of 110).
Results and discussion
In vivo
Results
- Irritation parameter:
- other: maximum average score
- Score:
- 39.8
- Remarks on result:
- other: moderately irritating
- Remarks:
- 24 hours
Any other information on results incl. tables
A
maximum average irritation score of 39.8 was obtained for nonwashed eyes
24 hours after treatment. The
score for washed eyes at this time was 33.3. Positive
staining occurred in all nonwashed eyes and 2 washed eyes at 24 hours. Staining
resolved in nonwashed and washed eyes by Days 7 and 4, respectively.
One animal whose eyes were not washed died on day 11. This
was not considered to be related to administration of the test material.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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