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Diss Factsheets
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EC number: 261-245-9 | CAS number: 58430-94-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
The mobility of aquatic invertebrates was not affected in a flow-through system at the highest concentration that could be maintained under test conditions with a mean measured concentrations of 5.4 mg/L after 48-hours.
Key value for chemical safety assessment
Additional information
The acute toxicity of the test substance 3,5,5-trimethylhexyl acetate to aquatic invertebrates (Daphnia magna) was investigated in two independent studies according to relevant OECD guidelines. The key study was conducted under flow-through conditions to maximise the test concentration of the volatile test item (Brougher et al. 2013). Test concentrations were measured and results were based on mean measured test concentrations, as the recovery of nominal concentrations was below 50% for all concentrations. No immobilisation of daphnids occurred at the highest concentration that could be maintained under test conditions with a mean measured concentration of 5.4 mg/L and the EC50 over the study duration of 48 hours was > 5.4 mg/L.
The supporting study exposed daphnids in a static system over a period of 48 hours (Caspers 2001), but the volatility of the test substance was not taken into account. The TOC was measured to confirm nominal test concentrations of 25, 50 and 100 mg/L. All measured concentrations were at or below the LOQ of the method (2 mg/L corresponding to 2.8 mg/L test substance) indicating deficiencies of the analytical method. At the highest nominal concentration of 100 mg/L, 30% of the daphnids were immobile after 48 hours. As the actual test concentration is not known, the results from this test (EC50 > 2.8 mg/L) are not taken into account in the hazard characterisation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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