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Diss Factsheets
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EC number: 205-565-9 | CAS number: 142-84-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Repeated dose toxicity: oral
NOAEL: 300 mg/kg bw/day
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Dose descriptor:
- NOAEL
- 300 mg/kg bw/day
- Study duration:
- subacute
- Species:
- rat
Additional information
In the available subacute study (14-day feeding; Virginia Chemical Inc., 1975) conducted similar to the OECD Guideline 407 (Repeated Dose 28-Day Oral Toxicity in Rodents; with some deviations: no heamatology, clinical chemistry, urinanalysis, neurobehavioural examination, ophthalmoscopic examination and water consumption; no data on analytical verification of doses), the test substance was administered in the diet to 3 groups of 10 animals per sex (albino rats) at dosage levels of 75, 150 and 300 mg/kg bw per day (an additional control group received the basal diet).
All animals survived the 2-weeks treatment. Patterns of appearance and behavior were not remarkable in any of the treated groups throughout the study. Gross observations at necropsy and subsequent microscopic examinations of liver and kidney sections of all animals revealed no evidence of compound-related tissue alterations in any of the treated groups.
Slight dose-related decreases in the rates of body weight gain were observed in the male and female treated groups at week 1 and in the male treated groups at week 2. The weight gain of the high-dose males was approximately 20% less than that of the control gain.
Mean food consumption values were also slightly lower at week 1 and 2 in the treated male animals than in the control group, suggesting that the high-dose animals reached an unpalatability threshold.
Based on the result of the present study, the only dose-related effect was the reduced body weight gain particularly in male animals, an effect which may partly resulted from the concomitant slightly reduced food consumption; therefore, the lowest observed effect level (LOEL) and the no observed adverse effect level (NOAEL) were 300 mg/kg bw per day, the high dose tested.
Justification for classification or non-classification
Based on the subacute study available, there is no need for classification for repeated dose toxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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