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Diss Factsheets
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EC number: 204-616-2 | CAS number: 123-30-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- June 26, 1997 - December 16, 1997
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Test procedure in accordance with generally accepted scientific standards and described in sufficient detail
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 305 C (Bioaccumulation: Test for the Degree of Bioconcentration in Fish)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Radiolabelling:
- yes
- Details on sampling:
- - Sampling intervals/frequency for test organisms: Every 2 weeks over 8 weeks
- Sampling intervals/frequency for test medium samples: Every 2 weeks over 8 weeks - Vehicle:
- yes
- Details on preparation of test solutions, spiked fish food or sediment:
- 7.36 mg of the test sample was dissolved in 1 mL dimethylformamide. Then this solution was diluted by water to be 300 ug/L concentration and 30 ug/L concentration. The solution with concentration of 300 ug/L was used as a stock solution for higher concentration, and the solution with concentration of 30 ug/L was used as a stock solution for lower concentration.
Stock solution and dilution water were provied with 0.7 mL/minute and 140 mL/minute respectivly into the test vessel with 60 L. - Test organisms (species):
- Cyprinus carpio
- Details on test organisms:
- TEST ORGANISM
- Common name: Japanese carp
- Source: Sugishima yougyojyo (in Japan)
- Weight at study initiation: Average body weight is 21.2 g before the exposure
- Length at study initiation: Average body length is 9.4 cm before the exposure
- Weight at termination: Not stated
- Feeding during test
- Food type: Compounded diet for carp
- Amount: 2 % to the body weight
- Frequency: Twice a day
ACCLIMATION
- Acclimation period: 68 days followed by 14 days
- Health during acclimation (any mortality observed): Fish wih any abnormalities was removed. - Route of exposure:
- aqueous
- Test type:
- flow-through
- Water / sediment media type:
- natural water: freshwater
- Total exposure / uptake duration:
- 8 wk
- Hardness:
- 38.5 mg/L
- Test temperature:
- 25 +/- 2 degree C over the exposure period
- pH:
- 7.6
- Dissolved oxygen:
- 6.4 - 7.3 mg/L for higher concentration
6.4 - 7.4 mg/L for lower concentration
6.7 - 7.8 mg/L for control - TOC:
- 1.2 mg/L
- Details on test conditions:
- TEST SYSTEM
-Type of the test system: Flow through system
-Test vessel: 60 L made of glass
- Renewal rate of test solution (frequency/flow rate):
Stock solution: 0.7 mL/minute
Dilution water: 140 mL/minute
Total: 203 L/day
- No. of organisms per vessel:
11 fish for higher concentration
11 fish for lower concentration
5 fish for control
- No. of vessels per concentration (replicates): One
- No. of vessels per control / vehicle control (replicates): One
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Tap water with treatment by activated carbon filtration
- Metals:
Alkylmercury: < 0.0005 mg/L
Mercury: < 0.0005 mg/L
Cadmium: < 0.005 mg/L
Cr6+: < 0.02 mg/L
Lead: < 0.005 mg/L
Arsenic: < 0.002 mg/L
Iron: < < 0.01 mg/L
Copper: < 0.005 mg/L
- Chlorine: Residula chlorine is < 0.01 mg/L
- Alkalinity: 42.0 mg/L
- Conductance: Electric conductivity is 138 us/cm - Nominal and measured concentrations:
- Nominal concentration
1.5 ug/L for higher concentration
0.15 ug/L for lower concentration - Reference substance (positive control):
- not required
- Lipid content:
- 3.5 %
- Type:
- BCF
- Value:
- 10 - 39
- Basis:
- whole body w.w.
- Remarks on result:
- other: Conc.in environment / dose:1.50 ug/L
- Type:
- BCF
- Value:
- 15 - 46
- Basis:
- whole body w.w.
- Remarks on result:
- other: Conc.in environment / dose:0.15 ug/L
- Results with reference substance (positive control):
- No positive control
- Details on results:
- - Mortality of test organisms: No mortaility was observed during the exposure period
- Behavioural abnormalities: No abnormal behavior was observed during the exposure period
- Mortality and/or behavioural abnormalities of control: No motality abnormal behavior were observed during the exposure period for control
- Results with vehicle control: No bio-concentration phenomena was observed for control which contains vehicle only - Validity criteria fulfilled:
- yes
- Conclusions:
- Bio-concentration factors of p-aminophenol are 10 - 39 for higher concentration and 15 - 46 for lower concentration.
Reference
The mean concentration of the test compound in water samples was maintained at 90% or higher of the set-up concentration.
Concentrations of p-aminophenol in the test water are as follows.
|
After 2 weeks |
After 4 weeks |
After 6 weeks |
After 8 weeks |
Higher concentration |
1.48 ug/L |
1.47 ug/L |
1.47 ug/L |
1.47 ug/L |
Lower concentration |
0.143 ug/L |
0.145 ug/L |
0.146 ug/L |
0.147 ug/L |
Bio-concentration factors of p-aminophenol are as follows.
|
After 2 weeks |
After 4 weeks |
After 6 weeks |
After 8 weeks |
Higher concentration |
13, 10 |
26, 13 |
23, 23 |
37, 39 |
Lower concentration |
19, 15 |
28, 21 |
25, 46 |
39, 42 |
Description of key information
Study conducted with reported BCF of 10-39 at 1.50 ug/l and 14-46 at 0.15 ug/l.
Key value for chemical safety assessment
- BCF (aquatic species):
- 46 L/kg ww
Additional information
Based on a BCF value in Cyprinus carpio that is ≤ 46, there is a low bioaccumulation potential in aquatic organisms.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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