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EC number: 923-037-2 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1980/09/24 - 1980/10/08
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: According to or similar to guideline study OECD 403. GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Hydrocarbons, C10-C12, isoalkanes, <2% aromatics
- EC Number:
- 923-037-2
- Cas Number:
- 0
- Molecular formula:
- None available - not a single isomer - see remarks
- IUPAC Name:
- Hydrocarbons, C10-C12, isoalkanes, <2% aromatics
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Albino; COX-SD
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Sex: 5 males; 5 females
- Weight at study initiation: 220 - 299 g
- Housing: individually
- Diet (e.g. ad libitum): Purina Rodent Lab Chow, ad libitum
- Water (e.g. ad libitum): ad libitum
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- Undiluted C10-C12 n-Paraffins was introduced into the chamber as a mist, by means of a DeVilbiss Nebulizer, at a delivery flow concentration of approximately 5.6 milligrams per liter of air at a total flow rate of ten liters per minute for a period of four hours (plus a 26-minute equilibration period*). NOTE: Prior to test exposure, exploratory runs were made with the inhalation equipment to establish a dose-setting relation of the equipment and the test compound.
*prior to the actual four-hour exposure, the test compound was introduced into the chamber for twenty-six minutes at the above flow rate in order that the test atmospheric concentration could reach theoretical equilibration (approximately 99%). The animals were within the inhalation chamber during the equilibration period. - Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 4 h
- Remarks on duration:
- plus 26 minute equilibration period
- Concentrations:
- 5.6 mg/L
- No. of animals per sex per dose:
- 5 males; 5 females
- Control animals:
- no
- Details on study design:
- Ten albino rats (five males and five females, COX-SD strain), weighing 220 to 299 grams, were used to evaluate the acute (single exposure) inhalation toxicity produced by the test compound, C10-C12 n-Paraffins when introduced in the form of a mist into a 57 liter capacity glass chamber containing the animals. Throughout the study, the animals were individually housed in metal, wire-bottomed cages elevated above the droppings. Each animal was examined before testing and only those animals from the supply on hand without observable defects were used. The animals were not fasted prior to exposure to inhalation of the test compound.
Undiluted C10-C12 n-Paraffins was introduced into the chamber as a mist, by means of a DeVilbiss Nebulizer, at a delivery flow concentration of approximately 5.6 milligrams per liter of air at a total flow rate of ten liters per minute for a period of four hours (plus a 26-minute equilibration period*). NOTE: Prior to test exposure, exploratory runs were made with the inhalation equipment to establish a dose-setting relation of the equipment and the test compound.
*prior to the actual four-hour exposure, the test compound was introduced into the chamber for twenty-six minutes at the above flow rate in order that the test atmospheric concentration could reach theoretical equilibration (approximately 99%). The animals were within the inhalation chamber during the equilibration period.
The animals were observed frequently for gross effects during the exposure. Upon removal from the chamber, the animals were cleaned with lukewarm tap water to remove any test compound having accumulated on their coats and were dried with towels. After drying, the animals were weighed and placed in their individual cages. Feed consisting of Purina Rodent Laboratory Chow (pelletized) and tap water were freely available at all times.
The animals were observed for gross effects at regular intervals during the remainder of the day of exposure and once daily thereafter for fourteen days. Body weights were recorded at seven and fourteen days post—exposure. Following the fourteen—day observation period, all surviving animals were sacrificed and necropsied. - Statistics:
- no details
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 5 600 mg/m³ air (nominal)
- Remarks on result:
- other: All animals survived
- Mortality:
- No mortality noted.
- Clinical signs:
- other: During the exposure, all of the animals displayed one or more of the following gross signs of test compound induced adverse effects: Slight to pronounced hypoactivity (10/10), malaise (10/10), and proneness (4/10). Following removal from the chamber and t
- Body weight:
- Body weight records of the animals showed constant weights except for two animals at seven days post-exposure (+/- 3 grams); the remaining animals at seven days, and all animals at fourteen days, post-exposure showed gains within expected limits.
- Other findings:
- Necropsy of the animals was performed at the termination of the study (fourteen days). Three animals had severe congestion of the lungs (approximately 30 to 50%); the findings for the other seven animals were unremarkable.
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- The LC50 for acute inhalation exposure to the test material (aerosol) is >5.6mg/L. Classification as an acute inhalation toxicant is not warranted under the new Regulation (EC) 1272/2008 on classification, labeling and packaging of substances and mixtures (CLP) or under Directive 67/518/EEC for dangerous substances and Directive 1999/45/EC for preparations.
- Executive summary:
Ten albino rats (five males and five females, COX-SD strain), weighing 220 to 299 grams, were exposed by the route of inhalation for four hours to undiluted C10-C12 n-paraffins in the form of a mist, at a delivery flow concentration of approximately 5.6 mg/L of test compound. All of the animals survived the exposure and the fourteen-day observation period which followed.
The LC50 for acute inhalation exposure to the test material (aerosol) is >5.6mg/L. Classification as an acute inhalation toxicant is not warranted under the new Regulation (EC) 1272/2008 on classification, labeling and packaging of substances and mixtures (CLP) or under Directive 67/518/EEC for dangerous substances and Directive 1999/45/EC for preparations.
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