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EC number: 210-871-0 | CAS number: 624-92-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- remark : GLP guideline study but the DMDS tested in this study did not correspond to the specifications of DMDS proposed for registration (high level of methyl mercaptan).
RAC concludes that the presence of methyl mercaptan as an impurity at such a low concentration does not affect the acute oral toxicity profile of DMDS ; the study is considered valid.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: EPA 40 CFR 163.81-1
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Dimethyl disulphide
- EC Number:
- 210-871-0
- EC Name:
- Dimethyl disulphide
- Cas Number:
- 624-92-0
- Molecular formula:
- C2H6S2
- IUPAC Name:
- (methyldisulfanyl)methane
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ORGANISMS:
- Source: Royalhart Colony, Newhampton, NY
- Age: no data
- Weight at study initiation: 163-269 g
- Adaptation period: 14 days
- Fasting before treatment: 18 hours
- Adaptation period : 14 days
HOUSING : The animals were housed individually in suspended stailess steel wire-bottomed cages
FOOD and WATER
- Food: Purina rat chow ad libitum
- Water: ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature : 68-72°F
- Relative humidity : no data
- Light/dark cycle : 12h/12h
- Ventilation : no data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: 3% CMC (carboxymethyl cellulose)
- Details on oral exposure:
- - Volume administered: no data
- Doses:
- 125, 188, 250, 375 and 500 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- Clinical signs, mortality and body weight gain were checked for a period of up to 14 days following the single administration of the test item. All animals were subjected to necropsy.
- Statistics:
- Litchfield-Wilcoxon method of probit analysis.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 190 mg/kg bw
- 95% CL:
- 150 - 240
- Remarks on result:
- other: Post-exposure clinical signs: sedation, hypotonia, dyspnea, piloerection and coma
- Mortality:
- Group Dose Mortality Mortality %
g/kg Male Female
1 0.125 0/5 1/5 10
2 0.188 5/5 1/5 60
3 0.250 3/5 4/5 70
4 0.375 5/5 5/5 100
5 0.50 5/5 5/5 100 - Clinical signs:
- other: Dose Level 0.125 g/kg: One female died approximately 2-1/2 hours after administration of the test material. The second female did not exhibit any movement on the day of dosing, but appeared to be recovered by the next morning, and did not exhibit any sign
- Gross pathology:
- Dose Level : 0.125 g/kg - Group 1: The necropsy of the 1 mortality showed evidence of pulmonary hemorrhage and an enlarged spleen. Necropsy of the survivons was unrevealing. All organs and tissues appeared normal.
Dose Level 0.188 g/kg: Necropsy of the mortalities on the day of dosing revealed evidence of pulmonary hemorrhage and one animal exhibited an enlarged spleen. Necropsy of the survivons was unreveallng. All organs and tissues appeared normal.
Dose Level 0.250 g/kg: Necropsy of the mortalities revealed evidence of pulmonary hemorrhage. One male exhibited gastro-intestinal hemorrhage and an enlarged spleen. Necropsy of survivors was unreveallng. All organs and tissues appeared normal.
Dose Level 0.375 g/kg: The necropsy revealed evidence of pulmonary hemorrhage in all but 2 rats. One male exhibited an enlarged spleen, and 1 female exhibited a gastro-intestinal hemorrhage. One male and 1 female did not exhibit any abnormal organs or tissues.
Dose Level 0.50 g/kg: 5 All animals died approximately 2-1/2 hours after administration of the test material. The necropsy revealed evidence of pulmonary hemorrhage in all animalis. One male and 1 female exhibited enlarged spleens, and 2 females exhibited gastro-intestinal hemorrhages.
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- Under these experimental conditions, the oral LD50 of DMDS was 190 (150 -240) mg/kg in female and male rats.
- Executive summary:
The Acute oral toxicity of DIMETHYL DISULFIDE was evaluated in male and female Wistar rats according to EPA 40 CFR 163.81-1and in compliance with principles of Good Laboratory Practices. Animals were treated with dose levels of 125, 188, 250, 375 and 500 mg/kg and then observed for 14 days for mortality, clinical signs and effect on body weight.
According to the dose levels, mortality was 10, 60, 70, 100 and 100% respectively.
Sedation, hypotonia, dyspnea, piloerection and coma, appeared just after the administration and disappeared after 24 hours. No effect was noted on the body weight gain of the surviving rats. Haemorragic stomachs was observed at the macroscopic examination of the rats dead on the first day (250 and 500 mg/kg)
Under these experimental conditions, the oral LD50 of DMDS was 190 (150 -240) mg/kg in female and male rats.
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