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Diss Factsheets
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EC number: 200-846-2 | CAS number: 75-18-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Specific investigations: other studies
Administrative data
- Endpoint:
- specific investigations: other studies
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- data not available
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Synergism between mercaptans and ammonia or fatty acids in the production of coma: a possible role for mercaptans in the pathogenesis of hepatic coma
- Author:
- Zieve L, Doizaki WM and Zieve FJ
- Year:
- 1 974
- Bibliographic source:
- J Lab Clin Med, 83(1), 16-28
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- GLP compliance:
- no
- Type of method:
- in vivo
Test material
- Reference substance name:
- Dimethyl sulphide
- EC Number:
- 200-846-2
- EC Name:
- Dimethyl sulphide
- Cas Number:
- 75-18-3
- Molecular formula:
- C2H6S
- IUPAC Name:
- (methylsulfanyl)methane
- Details on test material:
- dimethyl sulfide from Eastman Organic Chemicals, Rochester, NY.
Purity was confirmed by injecting the material received into the gas chromatograph and observing a single peak.
No other information available
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Holtzman or Sprague-Dawley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- rat body weight: 285 to 325 grams
No other information available
Administration / exposure
- Route of administration:
- inhalation: gas
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- no
- Duration of treatment / exposure:
- data not available
- Frequency of treatment:
- data not available
- Post exposure period:
- none
Doses / concentrations
- Remarks:
- Doses / Concentrations:
6 dose level between 7 and 12% by volume
Basis:
no data
- No. of animals per sex per dose:
- each point is based upon 3 to 5 rats
- Control animals:
- no
- Details on study design:
- Rats were placed singly in a large 4 liter glass chamber.
Blood concentration in dimethyl sulfide was determined
Results and discussion
- Details on results:
- The CD50 (dose at which 50 percent of animals become comatose) in rats was reported as 9.6% (v/v) dimethyl sulfide in air. The blood level of DMS at which coma occurred was 7 µmol/ml blood. A linear correlation was apparent between blood level and dose administered.
The rats went through a brief excitement phase before they became groggy. With doses producing coma in 50% of animals, the excitement phase lasted approximately 2 minutes, then passed quickly into a phase lasting 1 minute in which the rat became groggy and lethargic. This was followed in the next minutes or two by frank coma, the rat falling to its side and rolling over on its back as the chamber was tipped up slightly. With smaller doses the excitement phase and the pre-coma phase were prolonged; with larger doses the entire sequence occurred more quickly. If the rats were removed from the chamber as soon as he became comatose, the coma did not last more than 30 minutes as a rule, and upon recovery the rat appeared and remained alert and active.
Any other information on results incl. tables
DMS decreased the CD50 of the ammonium ion by approximately 50% and the incidence of coma rose from 0 to 100% when the maximum subcoma dose of DMS
(6.36% in air) and the ammonium ion were given together.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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