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Diss Factsheets
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EC number: 231-831-9 | CAS number: 7758-05-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from peer reviewed journal.
Data source
Reference
- Reference Type:
- publication
- Title:
- Case report of test chemical
- Author:
- Singalavanija et al.,
- Year:
- 2 000
- Bibliographic source:
- Retina,; 2000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- The clinical manifestations, toxic dosage of iodate, and ocular changes in five patients who had taken a test chemical overdose were analyzed. Electroretinography, visual evoked potential (VEP), and fundus fluorescein angiography (FA) were performed to study retinal function and changes.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Potassium iodate
- EC Number:
- 231-831-9
- EC Name:
- Potassium iodate
- Cas Number:
- 7758-05-6
- Molecular formula:
- HIO3.K
- IUPAC Name:
- potassium iodate
- Details on test material:
- - Name of test material (as cited in study report): Potassium iodate
- Substance type: Inorganic
- Physical state: Solid
Constituent 1
Test animals / tissue source
- Species:
- human
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Age at study initiation:22-65 yrs.
Test system
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- KIO3 solution at a concentration between 187 and 470 mg/kg body weight was ingested.
- Duration of treatment / exposure:
- 2 - 12 hours
- Observation period (in vivo):
- 3 months
- Number of animals or in vitro replicates:
- Two men and three women
Results and discussion
In vivo
Results
- Irritation parameter:
- other: Retinal pigment epithelial (RPE) window defects
- Basis:
- mean
- Time point:
- other: 2-12 hours
- Score:
- 20
- Max. score:
- 80
- Reversibility:
- not specified
- Remarks on result:
- other: Two men and three women (age 22-65 years) ingested KIO3 solution at a concentration between 187 and 470 mg/kg body weight. Visual acuity ranged from light perception with projection to counting fingers and decreased from 2 to 12 hours after ingestion.
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
- Conclusions:
- The test chemical can produce retinal toxicity that damages RPE and photoreceptor cells. The recovery of retinal function depends on the amount of chemical absorption, the regeneration of RPE, and the recovery function of photoreceptor cells. On the basis of observed effects, the test chemical can be considered as irritating to the human eyes.
- Executive summary:
The clinical manifestations, toxic dosage of iodate, and ocular changes in five patients who had taken a overdose of test chemical were analyzed. Electroretinography, visual evoked potential (VEP), and fundus fluorescein angiography (FA) were performed to study retinal function and changes.
Two men and three women (age 22-65 years) ingested test chemical solution at a concentration between 187 and 470 mg/kg body weight. Visual acuity ranged from light perception with projection to counting fingers and decreased from 2 to 12 hours after ingestion. Fundus FA showed bilateral extensive areas of retinal pigment epithelial (RPE) window defects, and electroretinography and VEP showed marked impairment of retinal function. Visual acuity improved from counting fingers to 20/80 in 3 months.
The test chemical can produce retinal toxicity that damages RPE and photoreceptor cells. The recovery of retinal function depends on the amount of chemical absorption, the regeneration of RPE, and the recovery function of photoreceptor cells.
On the basis of observed effects, the test chemical can be considered as irritating to the human eyes.
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