Registration Dossier
Registration Dossier
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EC number: 204-706-1 | CAS number: 124-63-0
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Test procedure in accordance with national standard methods with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Undiluted methanesulfonyl chloride and a 10% w/v dilution in PEG 400 were applied for 24 hours under an occlusive patch to the to the fur-clipped skin of rabbits. Then, the animals were observed for seven days.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Methanesulphonyl chloride
- EC Number:
- 204-706-1
- EC Name:
- Methanesulphonyl chloride
- Cas Number:
- 124-63-0
- Molecular formula:
- CH3ClO2S
- IUPAC Name:
- methanesulfonyl chloride
- Details on test material:
- Test article name : Methane sulfonyl chloride
Cas n°: 124-63-0
Origin: Pennwalt Corporation
Batch no. : no data
Purity: no data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: Albino
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Species: Rabbit
- Strain: albino
- Source: no data
- Age: no data
- Weight at dosing: no data
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
- Housing: no data
- Diet: no data
- Water: no data
- Temperature: no data
-Humidity: no data
-Air changes: no data
- Photoperiod: no data
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- polyethylene glycol
- Details on dermal exposure:
- Three albino rabbits were treated dermally with a single dose of 2000 mg/kg and 6 additional rabbits were treated with a single dose of 200 mg/kg (2.0 ml/kg of a 10% w/v dilution in PEG 400). Individual dose were applied to the fur-clipped skin of the trunk under a pre-fitted impervious sleeve on each animal.
- Duration of exposure:
- 24 hours
- Doses:
- 200 (10% in PEG 400), 2000 (undiluted) mg/kg
- No. of animals per sex per dose:
- 3 or 6
- Control animals:
- no
- Details on study design:
- After a skin-contact period of 24 hours, the sleeves were removed and surviving animals were observed for seven days. No additional data available.
- Statistics:
- not apprpriate
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 200 - 2 000 mg/kg bw
- Mortality:
- - 2000 mg/kg (undiluted) : Mortality 3/3.
- 200 mg/kg (10% dilution) : No mortality. - Clinical signs:
- other: - 2000 mg/kg (undiluted) : initial skin contact evoked an intense pain reaction. One of the 3 rabbits died 30 min after exposure and the other 2 rabbits died during the following night. In each case the skin of the entire trunk was necrotic gray in app
- Gross pathology:
- no data
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category III
- Remarks:
- Migrated information Criteria used for interpretation of results: other: REGULATION (EC) No 1272/2008 OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL of 16 December 2008
- Conclusions:
- The acute dermal LD50 of Methanesulfonyl chloride was estimated to be greater than 200 mg/kg and lower than 2000 mg/kg in the rabbit.
- Executive summary:
Three albino rabbits were treated dermally with a single dose of 2000 mg/kg of methanesulfonyl chloride (purity unknown) and 6 additional rabbits were treated with a single dose of 200 mg/kg (2.0 ml/kg of a 10% w/v dilution in PEG 400). Individual dose were applied to the fur-clipped skin of the trunk under a pre-fitted impervious sleeve on each animal. After a skin-contact period of 24 hours, the sleeves were removed and surviving animals were observed for seven days.
No mortality was observed at 200 mg/kg and all of the animals remained asymptomatic and gained body weight during the observation period. When exposures were terminated, a well-defined erythema (score 2) was present over the entire trunk of each rabbit
All rabbits died at 2000 mg/kg. Initial skin contact evoked an intense pain reaction. One of the 3 rabbits died 30 min after exposure and the other 2 rabbits died during the following night. In each case the skin of the entire trunk was necrotic gray in appearance and the eyes were irritated.
The acute dermal LD50 of Methanesulfonyl chloride was estimated to be greater than 200 mg/kg and lower than 2000 mg/kg in the rabbit.
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