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EC number: 232-075-2 | CAS number: 7785-21-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
All three in vitro tests in genetic toxicity showed negative results. Therefore, there is no need to carry out in vivo studies in genetic toxicity. There is no reason to believe that the negative results would not be relevant to humans.
Justification for selection of genetic toxicity endpoint
Conclusion based on the following assays: Bacterial reverse mutation assay (Ames test); Mammalian cell gene mutation assay; In vitro mammalian chromosome aberration test.
Read across from ammonium dihydrogenorthophosphate and diammonium phosphate to magnesium ammonium phosphate is considered justified based on following background:
Since magnesium ammonium phosphate, ammonium dihydrogenorthophosphate and diammonium phosphate dissociate to their respective ammonium, (magnesium) and phosphate ions, it is considered acceptable to approach the assessment of magnesium ammonium phosphate based on the individual components.
Phosphate, ammonium and magnesium, as essential nutrients for life are not known as mutagenic.
Given the previous evaluations of magnesium, ammonium and phosphate salts as food additives and as nutrient sources by the EFSA (European Food Safety Authority), SCF (Scientific Committee on Food ) BfR (Federal Institute for Risk Assessment) and JECFA (Joint FAO/WHO Expert Committee on Food Additives) and taking into account that available information on their toxicity did not identify toxicogical effects, any additional testing would be unjustified.
Short description of key information:
Negative in all tests conducted:
Bacterial reverse mutation assay with diammonium phosphate:
The results of the Bacterial Reverse Mutation Assay according to OECD guideline 471 indicate that, under the conditions of the study, Diammonium Phosphate (DAP) did not cause a positive response in the presence and absence of Aroclor-induced rat liver S9.
In vitro mamalian chromosome aberration assay with diammonium phosphate:
Under the conditions of the assay according to OECD guideline 473, Diammoniumn Phosphate (DAP) was concluded to be negative for the induction of
structural and numerical chromosome aberrations in CHO cells.
Mammalian cell gene mutation assay with ammonium dihydrogenorthophosphate:
Ammonium dihydrogenorthophosphate was not mutagenic in the mouse lymphoma L5178Y test system under the experimental conditions according to OECD guideline 476.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
According to the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) of the United Nations (2007) and Regulation (EC) No 1272/2008 on classification, labelling and packaging of substances and mixtures the substance is not classified.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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