Registration Dossier
Registration Dossier
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EC number: 212-079-0 | CAS number: 760-23-6
Endpoint summary
Administrative data
Description of key information
-Acute Oral Toxicity (rat, OECD guideline 401); LD50: male=943 mg/kg; female=946 mg/kg;
-Acute Inhalation Toxicity (rat, no guideline); LC50= 10.89 mg/L/4h;
-Acute Dermal Toxicity (rabbit, OECD guideline 402); LD50>2000 mg/kg
Key value for chemical safety assessment
Additional information
Acute toxicity data are reported for rats, mice, and rabbits. The LD50 value of about 940 mg/kg bw and the LC50 value of 10.89 mg/L/4h. Among the above, an oral rat study (MHW, Japan) was indentified as the key study because it conducted according to OECD guideline and GLP conditions. Male and female Crj:CD(SD) rats were administered orally at doses of 670, 804, 965, 1158, 1389 and 1667 mg/kg and observed for two weeks. Clinical signs of decreased locomotor activity, deep respiration, ptosis, salivation, flaccidity, adoption of a prone position, plioerection and perinasal soiling with nasal discharge were observed in the treated groups. At autopsy, lung enlargement, urine retention and crystalline materials in the urinary bladder, and hemorrhagic black spots in the glandular stomach mucosa were observed in animals. Fatalities were found for both sexes at doses of more than 804 mg/kg. The dermal LD50 in rabbits was > 2000 mg/kg bw (no fatalities) in a guideline study and under GLP. The acute toxicity of 3,4-dichlorobut-1-ene, is low in dermal application.
Justification for classification or non-classification
Based on the test results, 3,4 -dichlorobut-1-ene is to be classified as Xn R22/20 according to DSD-DPD, and Acute Tox 4, according to CLP (H302, H332, Harmful if inhaled and if swallowed), according to the DSD classification criteria.
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