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EC number: 279-632-6 | CAS number: 80939-62-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- November 23, 1981 - December 7, 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with restrictions (study was performed under QAU): - occlusive conditions - exposure period of 24 hours
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- (occlusive conditions, exposure period of 24 hours)
- Qualifier:
- according to guideline
- Guideline:
- other: United States Environmental Agency (EPA) § 163.81-5 "Primary dermal irritation study". Federal Register, Vol. 43, No. 163, August 22, 1978
- GLP compliance:
- no
Test material
- Reference substance name:
- Amines, C11-14-branched alkyl, monohexyl and dihexyl phosphates
- EC Number:
- 279-632-6
- EC Name:
- Amines, C11-14-branched alkyl, monohexyl and dihexyl phosphates
- Cas Number:
- 80939-62-4
- Molecular formula:
- Unspecified
- IUPAC Name:
- Amines, C11-14-branched alkyl, monohexyl and dihexyl phosphates
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Kleintierfarm Madoerin AG, CH-4414 Fuellinsdorf
- Weight at study initiation: 2 to 3 kg
- Housing: individually in metal cages
- Diet (ad libitum): standard rabbit food - NAFAG, No. 814
- Water (ad libitum): drinking water
- Acclimation period: min. of 4 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/- 2
- Humidity (%): 55 +/- 10
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: shaved (one flank), shaved and scarified (other flank)
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 ml - Duration of treatment / exposure:
- 24 hours
- Observation period:
- 14 days
- Number of animals:
- 3 male ande 3 female animals
- Details on study design:
- TEST SITE
- Area of exposure: both side flanks (one side was just shaved, the other one was shaved and scarified)
- Type of wrap if used: gauze patch (2.5x2.5 cm), patches were covered with an impermeable material and were fastened to the body of the rabbit with adhesive tape.
SCORING SYSTEM:
Erythema and eschar formation
No erythema 0
Very slight erythema (barely perceptible) 1
Well defined erythema 2
Moderate to severe erythema 3
Severe erythema (beet redness) to slight eschar
formation (injuries in depth) 4
Total possible erythema score: 4
Edema formation
No edema 0
Very slight edema (barely perceptible) 1
Slight edema (edges of area well defined by definite raising) 2
Moderate edema (raised approximately 1 mm) 3
Severe edema (raised more than 1 mm and extending beyond area of exposure) 4
Total possible edema score: 4
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24 h- 48 h - 72 h
- Score:
- 2.83
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 14 days (all animals were affected)
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24 h - 48 h - 72 h
- Score:
- 2.5
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 14 days (all animals were affected)
- Irritation parameter:
- primary dermal irritation index (PDII)
- Score:
- 5
- Max. score:
- 8
- Remarks on result:
- other: The scores read after 24 and 72 hours for erythema and edema for the intact as well as for the abraded skin were summed up and divided by 4 (FHSLA § 191.11): The test substance caused a marked irritation when applied to intact and abraded rabbit skin.
- Irritant / corrosive response data:
- The following observations were made in practically all the application sites in the course of the experiment, in addition to the scores: erythema greater than the surface of compound patch, ischaemic areas, cracked skin, scales formation.
- Other effects:
- Besides transient periods of anorexia in few animals no other symptoms were observed. One female animal died at day 8 of test independently of the compound administration. No gross lesions were found.
Any other information on results incl. tables
In the following tables, only the results of the treatment of the intact skin side is given, as testing on intact skin is recommended by OECD guideline 404 and the basis for skin irritation assessment.
Table 1: Evaluation of erythema an edema in male animals after a 24 hours treatment under occlusive conditions:
Observation time |
Animal |
Erythema |
Edema |
24 hours |
1 |
3 |
3 |
|
2 |
2 |
2 |
|
3 |
3 |
3 |
48 hours |
1 |
3 |
3 |
|
2 |
3 |
2 |
|
3 |
3 |
3 |
72 hours |
1 |
4 |
4 |
|
2 |
3 |
2 |
|
3 |
4 |
3 |
14 days |
1 |
4 |
4 |
|
2 |
3 |
2 |
|
3 |
4 |
3 |
Mean (24-48-72h) |
1 |
3.33 |
3.33 |
|
2 |
2.66 |
2 |
|
3 |
3.33 |
3 |
Mean |
|
3.11 |
2.78 |
Table 2: Evaluation of erythema an edema in female animals after a 24 hours treatment under occlusive conditions:
Observation time |
Animal |
Erythema |
Edema |
24 hours |
1 |
2 |
2 |
|
2 |
2 |
2 |
|
3 |
3 |
2 |
48 hours |
1 |
2 |
2 |
|
2 |
3 |
3 |
|
3 |
3 |
2 |
72 hours |
1 |
2 |
2 |
|
2 |
3 |
3 |
|
3 |
3 |
2 |
14 days |
1 |
dead |
dead |
|
2 |
4 |
3 |
|
3 |
4 |
3 |
Mean (24-48-72h) |
1 |
2 |
2 |
|
2 |
2.66 |
2.66 |
|
3 |
3 |
2 |
Mean |
|
2.55 |
2.22 |
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the conditions of the present experiment the test article was found to cause a marked irritation when applied to intact and abraded rabbit skin.
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